Modulating ROS to overcome multidrug resistance in cancer

Q Cui, JQ Wang, YG Assaraf, L Ren, P Gupta… - Drug Resistance …, 2018 - Elsevier
The successful treatment of cancer has significantly improved as a result of targeted therapy
and immunotherapy. However, during chemotherapy, cancer cells evolve and can acquire …

Home as the new frontier for the treatment of COVID-19: the case for anti-inflammatory agents

N Perico, M Cortinovis, F Suter… - The Lancet Infectious …, 2023 - thelancet.com
Summary COVID-19, caused by SARS-CoV-2, is characterised by a broad spectrum of
symptom severity that requires varying amounts of care according to the different stages of …

Chiral alkyl amine synthesis via catalytic enantioselective hydroalkylation of enecarbamates

D Qian, S Bera, X Hu - Journal of the American Chemical Society, 2021 - ACS Publications
Chiral alkyl amines are omnipresent as bioactive molecules and synthetic intermediates.
The catalytic and enantioselective synthesis of alkyl amines from readily accessible …

The rise and fall of aspirin in the primary prevention of cardiovascular disease

I Raber, CP McCarthy, M Vaduganathan, DL Bhatt… - The Lancet, 2019 - thelancet.com
Aspirin is one of the most frequently used drugs worldwide and is generally considered
effective for the secondary prevention of cardiovascular disease. By contrast, the role of …

Inflammation: Biochemistry, cellular targets, anti-inflammatory agents and challenges with special emphasis on cyclooxygenase-2

B Kaur, P Singh - Bioorganic Chemistry, 2022 - Elsevier
Keeping in view the involvement of inflammation in the pathogenesis of several diseases
including cancer, diabetes, neurodegenerative disorders and rheumatoid arthritis, herein …

Aspirin for prevention of preeclampsia

A Atallah, E Lecarpentier, F Goffinet, M Doret-Dion… - Drugs, 2017 - Springer
Aspirin is currently the most widely prescribed treatment in the prevention of cardiovascular
complications. The indications for the use of aspirin during pregnancy are, however, the …

Physiological and molecular determinants of embryo implantation

S Zhang, H Lin, S Kong, S Wang, H Wang… - Molecular aspects of …, 2013 - Elsevier
Embryo implantation involves the intimate interaction between an implantation-competent
blastocyst and a receptive uterus, which occurs in a limited time period known as the …

Therapeutic potential of resveratrol: the in vivo evidence

JA Baur, DA Sinclair - Nature reviews Drug discovery, 2006 - nature.com
Resveratrol, a constituent of red wine, has long been suspected to have cardioprotective
effects. Interest in this compound has been renewed in recent years, first from its …

Diclofenac: an update on its mechanism of action and safety profile

TJ Gan - Current medical research and opinion, 2010 - Taylor & Francis
Background: Diclofenac is a proven, commonly prescribed nonsteroidal anti-inflammatory
drug (NSAID) that has analgesic, anti-inflammatory, and antipyretic properties, and has been …

CYCLOOXYGENASES 1 AND 2

JR Vane, YS Bakhle, RM Botting - Annual review of …, 1998 - annualreviews.org
▪ Abstract Cyclooxygenase (COX), first purified in 1976 and cloned in 1988, is the key
enzyme in the synthesis of prostaglandins (PGs) from arachidonic acid. In 1991, several …