Modulating ROS to overcome multidrug resistance in cancer
The successful treatment of cancer has significantly improved as a result of targeted therapy
and immunotherapy. However, during chemotherapy, cancer cells evolve and can acquire …
and immunotherapy. However, during chemotherapy, cancer cells evolve and can acquire …
Home as the new frontier for the treatment of COVID-19: the case for anti-inflammatory agents
N Perico, M Cortinovis, F Suter… - The Lancet Infectious …, 2023 - thelancet.com
Summary COVID-19, caused by SARS-CoV-2, is characterised by a broad spectrum of
symptom severity that requires varying amounts of care according to the different stages of …
symptom severity that requires varying amounts of care according to the different stages of …
Chiral alkyl amine synthesis via catalytic enantioselective hydroalkylation of enecarbamates
Chiral alkyl amines are omnipresent as bioactive molecules and synthetic intermediates.
The catalytic and enantioselective synthesis of alkyl amines from readily accessible …
The catalytic and enantioselective synthesis of alkyl amines from readily accessible …
The rise and fall of aspirin in the primary prevention of cardiovascular disease
I Raber, CP McCarthy, M Vaduganathan, DL Bhatt… - The Lancet, 2019 - thelancet.com
Aspirin is one of the most frequently used drugs worldwide and is generally considered
effective for the secondary prevention of cardiovascular disease. By contrast, the role of …
effective for the secondary prevention of cardiovascular disease. By contrast, the role of …
Inflammation: Biochemistry, cellular targets, anti-inflammatory agents and challenges with special emphasis on cyclooxygenase-2
B Kaur, P Singh - Bioorganic Chemistry, 2022 - Elsevier
Keeping in view the involvement of inflammation in the pathogenesis of several diseases
including cancer, diabetes, neurodegenerative disorders and rheumatoid arthritis, herein …
including cancer, diabetes, neurodegenerative disorders and rheumatoid arthritis, herein …
Aspirin for prevention of preeclampsia
A Atallah, E Lecarpentier, F Goffinet, M Doret-Dion… - Drugs, 2017 - Springer
Aspirin is currently the most widely prescribed treatment in the prevention of cardiovascular
complications. The indications for the use of aspirin during pregnancy are, however, the …
complications. The indications for the use of aspirin during pregnancy are, however, the …
Physiological and molecular determinants of embryo implantation
S Zhang, H Lin, S Kong, S Wang, H Wang… - Molecular aspects of …, 2013 - Elsevier
Embryo implantation involves the intimate interaction between an implantation-competent
blastocyst and a receptive uterus, which occurs in a limited time period known as the …
blastocyst and a receptive uterus, which occurs in a limited time period known as the …
Therapeutic potential of resveratrol: the in vivo evidence
JA Baur, DA Sinclair - Nature reviews Drug discovery, 2006 - nature.com
Resveratrol, a constituent of red wine, has long been suspected to have cardioprotective
effects. Interest in this compound has been renewed in recent years, first from its …
effects. Interest in this compound has been renewed in recent years, first from its …
Diclofenac: an update on its mechanism of action and safety profile
TJ Gan - Current medical research and opinion, 2010 - Taylor & Francis
Background: Diclofenac is a proven, commonly prescribed nonsteroidal anti-inflammatory
drug (NSAID) that has analgesic, anti-inflammatory, and antipyretic properties, and has been …
drug (NSAID) that has analgesic, anti-inflammatory, and antipyretic properties, and has been …
CYCLOOXYGENASES 1 AND 2
JR Vane, YS Bakhle, RM Botting - Annual review of …, 1998 - annualreviews.org
▪ Abstract Cyclooxygenase (COX), first purified in 1976 and cloned in 1988, is the key
enzyme in the synthesis of prostaglandins (PGs) from arachidonic acid. In 1991, several …
enzyme in the synthesis of prostaglandins (PGs) from arachidonic acid. In 1991, several …