Drug development is a lengthy and costly process that proceeds through several stages
from target identification to lead discovery and optimization, preclinical validation and …

Trillions of microbes have evolved with and continue to live on and within human beings. A
variety of environmental factors can affect intestinal microbial imbalance, which has a close …

Stem-cell-derived epithelial organoids are routinely used for the biological and biomedical
modelling of tissues. However, the complexity, lack of standardization and quality control of …

The in vitro organoid model is a major technological breakthrough that has already been
established as an essential tool in many basic biology and clinical applications. This near …

Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-
throughput screening (HTS), but the complexity of organoid cultures poses a significant …

Abstract We introduce Digital microfluidic Isolation of Single Cells for-Omics (DISCO), a
platform that allows users to select particular cells of interest from a limited initial sample size …

Background & Aims The human gut microbiota is becoming increasingly recognized as a
key factor in homeostasis and disease. The lack of physiologically relevant in vitro models to …

Understanding the importance of the gut microbiome on modulation of host health has
become a subject of great interest for researchers across disciplines. As an intrinsically …

Although the elementary unit of biology is the cell, high-throughput methods for the
microscale manipulation of cells and reagents are limited. The existing options either are …

Abstract 3D in vitro model systems such as spheroids and organoids provide an opportunity
to extend the physiological understanding using recapitulated tissues that mimic …