Background An increased access of research laboratories to isolated human islets has
improved our understanding of the biology of the endocrine pancreas and hence the …

Type 1 diabetes mellitus is an autoimmune disease that is characterized by the destruction
of the islets of Langerhans cells which produce insulin. The current gold standard treatment …

Ischaemia impairs organ quality during preservation in a time‐dependent manner, due to a
lack of oxygen supply. Its impact on pancreas and islet transplantation outcome has been …

During intra-portal pancreatic islet transplantation (PITx), innate immune reactions such as
the instant blood mediated inflammatory reaction (IBMIR) cause an immediate loss of islets …

Organs from donors after controlled circulatory death (DCD III) exhibit a higher risk for graft
dysfunction due to an initial period of warm ischemia. This procurement condition can also …

The instant blood-mediated inflammatory reaction (IBMIR) has been studied in whole blood
models of human allo-islet transplantation for short periods (< 6 h). Beyond this time frame …

The aim of this study was to investigate the effects of elevated donor HbA1c levels (type 2
diabetes, T2D) on the islet yield and functionality postisolation. In this retrospective analysis …

Background Pancreatic islet transplantation offers a promising biotherapy for the treatment
of type 1 diabetes, but this procedure has met significant challenges over the years. One …

Better results have been recently reported in clinical pancreatic islet transplantation (ITX)
due mostly to improved isolation techniques and immunosuppression; however, some …

Organs from hypernatremia (elevated Na+) donors when used for transplantation have had
dismal outcomes. However, islet isolation from hypernatremic donors for both …