An inflammatory microenvironment, either conferred by an underlying chronic overt or
smoldering inflammatory condition constitutes a prerequisite and fuel to essentially all …

Macrophages are found in tissues, body cavities, and mucosal surfaces. Most tissue
macrophages are seeded in the early embryo before definitive hematopoiesis is …

Intratumoral immune cells are crucial for tumor control and antitumor responses during
immunotherapy. Immune cell trafficking into tumors is mediated by binding of specific …

CD38 is a molecule that can act as an enzyme, with NAD-depleting and intracellular
signaling activity, or as a receptor with adhesive functions. CD38 can be found expressed …

Age-related macular degeneration is a prevalent neuroinflammatory condition and a major
cause of blindness driven by genetic and environmental factors such as obesity. In diseases …

Nicotinamide adenine dinucleotide (NAD+) is modulated by conditions of metabolic stress
and has been reported to decline with aging in preclinical models, but human data are …

Renal cell carcinoma stands out as one of the most immune-infiltrated tumors in pan-cancer
comparisons. Features of the tumor microenvironment heavily affect disease biology and …

BACKGROUND. While mitochondria play an important role in innate immunity, the
relationship between mitochondrial dysfunction and inflammation in heart failure (HF) is …

Nicotinamide adenine dinucleotide (NAD+) is a ubiquitous metabolite that takes part in
many key redox reactions. NAD+ biosynthesis and NAD+-consuming enzymes have been …

Schistosomiasis is an infection caused by contact with Schistosoma-contaminated water and
affects more than 230 million people worldwide with varying morbidity. The roles of T helper …