With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

The first-order rate constants for the hydrolysis of a phosphodiester bond under
physiological conditions have been estimated to be 6 X 10-9 and 6 X 10-10 min-1 for single …

An improved dynamic programming algorithm is reported for RNA secondary structure
prediction by free energy minimization. Thermodynamic parameters for the stabilities of …

The first step in CRISPR-Cas9-mediated genome editing is the cleavage of target DNA
sequences that are complementary to so-called spacer sequences in CRISPR guide RNAs …

This communication presents results from molecular dynamics (MD) simulations with
AMBER 4.11 and the Cornell et al? force field of three different, fully solvated, fully charged …

RNA molecules exhibit complex structures in which a large fraction of the bases engage in
non‐Watson–Crick base pairing, forming motifs that mediate long‐range RNA–RNA …

The recently discovered functions of RNA dramatically expand the cellular roles for this
macromolecule. RNA can no longer be viewed as a passive element, working simply as an …

The 16S and 23S rRNA higher-order structures inferred from comparative analysis are now
quite refined. The models presented here differ from their immediate predecessors only in …

The inherent chemical instability of RNA under physiological conditions is primarily due to
the spontaneous cleavage of phosphodiester linkages via intramolecular transesterification …

The ribosome is a large multifunctional complex composed of both RNA and proteins.
Biophysical methods are yielding low-resolution structures of the overall architecture of …