Cancer involves defects in the mechanisms underlying cell proliferation, death and
migration. Calcium ions are central to these phenomena, serving as major signalling agents …

Calcium (Ca2+) signaling and the modulation of intracellular calcium ([Ca2+] i) levels play
critical roles in several key processes that regulate cellular survival, growth, differentiation …

A low vitamin D status and inadequate calcium intake are important risk factors for various
types of cancer. Ecological studies using solar UV-B exposure as an index of vitamin D3 …

Breast cancer (BC) is the leading cancer in the world in terms of incidence and mortality in
women. However, the mechanism by which BC develops remains largely unknown. The …

Plasma-membrane-localized Orai1 ion channel subunits interacting with ER-localized
STIM1 molecules comprise the major subunit composition responsible for calcium release …

A compromised vitamin D status, characterized by low 25-hydroxyvitamin D (25-(OH) D)
serum levels, and a nutritional calcium deficit are widely encountered in European and …

P-type ATPases catalyze the selective active transport of ions like H+, Na+, K+, Ca2+, Zn2+,
and Cu2+ across diverse biological membrane systems. Many members of the P-type …

Low level light therapy uses light of specific wavelengths in red and near-infrared spectral
range to treat various pathological conditions. This light is able to modulate biochemical …

Ion channels have been shown to be involved in oncogenesis and efforts are being poured
in to target the ion channels. There are many clinically approved drugs with ion channels as …

Pancreatic ductal adenocarcinoma (PDAC) causes annually well over 400,000 deaths world-
wide and remains one of the major unresolved health problems. This exocrine pancreatic …