Haematopoietic stem cells (HSCs) emerge during embryogenesis and give rise to the adult
haematopoietic system. Understanding how early haematopoietic development occurs is of …

• Introduction• The proof‐of‐concept in vivo: the cell, the read‐out and the animal model‐The
CEPC: Still a putative cell‐Do CEPCs play an essential role in vascular (patho) physiology …

Abstract Hematopoietic Stem/Progenitor cells (HSPCs) are endowed with the role of
maintaining a diverse pool of blood cells throughout the human life. Despite recent efforts …

Tracing the emergence of the first hematopoietic stem cells (HSCs) in human embryos,
particularly the scarce and transient precursors thereof, is so far challenging, largely due to …

Embryonic stem (ES) cells have the potential to serve as an alternative source of
hematopoietic precursors for transplantation and for the study of hematopoietic cell …

Blood cells are constantly produced in the bone marrow (BM) of adult mammals. This
constant turnover ultimately depends on a rare population of progenitors that displays self …

Human hematopoiesis is initiated in the yolk sac during the third week of development. At
the same time the capacity to produce blood cells also arises in the embryo, within the …

We have traced emerging hematopoietic cells along human early ontogeny by culturing
embryonic tissue rudiments in the presence of stromal cells that promote myeloid and B cell …

Hematopoietic cells arise first in the third week of human ontogeny inside yolk sac
developing blood vessels, then, one week later and independently, from the wall of the …

Background and Objectives Mesenchymal stem/progenitor cells (MSCs) are multipotent
progenitors that differentiate into such lineages as bone, fat, cartilage and stromal cells that …