Bee venom: From venom to drug
Insects of the order Hymenoptera have a defensive substance that contains many
biologically active compounds. Specifically, venom from honeybees (Apis mellifera) contains …
biologically active compounds. Specifically, venom from honeybees (Apis mellifera) contains …
Tissue damaging toxins in snake venoms: Mechanisms of action, pathophysiology and treatment strategies
Snakebite envenoming is an important public health issue responsible for mortality and
severe morbidity. Where mortality is mainly caused by venom toxins that induce …
severe morbidity. Where mortality is mainly caused by venom toxins that induce …
High-throughput proteomics and in vitro functional characterization of the 26 medically most important elapids and vipers from sub-Saharan Africa
Venomous snakes are important parts of the ecosystem, and their behavior and evolution
have been shaped by their surrounding environments over the eons. This is reflected in their …
have been shaped by their surrounding environments over the eons. This is reflected in their …
Biogeographical venom variation in the Indian spectacled cobra (Naja naja) underscores the pressing need for pan-India efficacious snakebite therapy
RR Senji Laxme, S Attarde, S Khochare… - PLOS neglected …, 2021 - journals.plos.org
Background Snake venom composition is dictated by various ecological and environmental
factors, and can exhibit dramatic variation across geographically disparate populations of …
factors, and can exhibit dramatic variation across geographically disparate populations of …
Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms
SR Hall, SA Rasmussen, E Crittenden… - Nature …, 2023 - nature.com
Morbidity from snakebite envenoming affects approximately 400,000 people annually.
Tissue damage at the bite-site often leaves victims with catastrophic life-long injuries and is …
Tissue damage at the bite-site often leaves victims with catastrophic life-long injuries and is …
The concept of big four: road map from snakebite epidemiology to antivenom efficacy
G Gopal, S Muralidar, D Prakash… - International journal of …, 2023 - Elsevier
Snake envenomation is a life-threatening disease caused by the injection of venom toxins
from the venomous snake bite. Snakebite is often defined as the occupational or domestic …
from the venomous snake bite. Snakebite is often defined as the occupational or domestic …
An in vitro methodology for discovering broadly-neutralizing monoclonal antibodies
Broadly-neutralizing monoclonal antibodies are of high therapeutic utility against infectious
diseases caused by bacteria and viruses, as well as different types of intoxications …
diseases caused by bacteria and viruses, as well as different types of intoxications …
Terrestrial venomous animals, the envenomings they cause, and treatment perspectives in the Middle East and North Africa
The Middle East and Northern Africa, collectively known as the MENA region, are inhabited
by a plethora of venomous animals that cause up to 420,000 bites and stings each year. To …
by a plethora of venomous animals that cause up to 420,000 bites and stings each year. To …
Development of a high-throughput in vitro screening method for the assessment of cell-damaging activities of snake venoms
MA Bittenbinder, L Capinha… - PLOS Neglected …, 2023 - journals.plos.org
Snakebite envenoming is a globally important public health issue that has devastating
consequences on human health and well-being, with annual mortality rates between 81,000 …
consequences on human health and well-being, with annual mortality rates between 81,000 …
Current insights in the mechanisms of cobra venom cytotoxins and their complexes in inducing toxicity: implications in antivenom therapy
Cytotoxins (CTXs), an essential class of the non-enzymatic three-finger toxin family, are
ubiquitously present in cobra venoms. These low-molecular-mass toxins, contributing to …
ubiquitously present in cobra venoms. These low-molecular-mass toxins, contributing to …