Genetics in endocrinology: genetic variation in deiodinases: a systematic review of potential clinical effects in humans

H Verloop, OM Dekkers, RP Peeters… - European journal of …, 2014 - academic.oup.com
Iodothyronine deiodinases represent a family of selenoproteins involved in peripheral and
local homeostasis of thyroid hormone action. Deiodinases are expressed in multiple organs …

Genetic abnormalities in thyroid hormone deiodinases

PN Taylor, R Peeters, CM Dayan - Current opinion in …, 2015 - journals.lww.com
The clinical importance of genetic variation in the deiodinases has yet to be fully elucidated
and their impact is likely to vary between individuals and body systems dependent on …

The Thr92Ala polymorphism in the type 2 deiodinase gene is linked to depression in patients with COVID-19 after hospital discharge

DCA Beltrão, FEL Beltrão, G Carvalhal… - Frontiers in …, 2024 - frontiersin.org
Background The Thr92Ala-DIO2 polymorphism has been associated with clinical outcomes
in hospitalized patients with COVID-19 and neuropsychiatric diseases. This study examines …

Effect of DIO2 Gene Polymorphism on Thyroid Hormone Levels and Its Correlation with the Severity of Schizophrenia in a Pakistani Population

F Hanif, Q Amir, W Washdev - International Journal of Molecular Sciences, 2024 - mdpi.com
Low levels of triiodothyronine (T3) in the brain lead to increased dopamine receptor
sensitivity, potentially resulting in schizophrenia. Iodothyronine deiodinase 2 (DIO2) is the …

[PDF][PDF] Type II deiodinase polymorphisms and serum thyroid hormone levels in patients with mild cognitive impairment

M Luo, XH Zhou, T Zou, K Keyim, LM Dong - Genet Mol Res, 2015 - funpecrp.com.br
We investigated type II deiodinase (DIO2) polymorphisms and serum thyroid hormone levels
in subjects with mild cognitive impairment (MCI) in a Uygur population. We studied the DIO2 …

Assessment of children in the autistic spectrum disorder that carry the Thr92Ala-DIO2 polymorphism

AA e Marcondes, TGB Gomez, TT Ravache… - Journal of …, 2021 - Springer
Introduction A polymorphism in the type 2 deiodinase (Thr92Ala-DIO2) gene has been
associated with behavioral and cognitive dysfunction as well as neurodegeneration and …