Hippocampal atrophy, as evidenced using magnetic resonance imaging (MRI), is one of the
most validated, easily accessible and widely used biomarkers of Alzheimer's disease (AD) …

Alzheimer's disease (AD) is the most common cause of dementia, affecting the central
nervous system (CNS) through the accumulation of intraneuronal neurofibrillary tau tangles …

APOE-ε4 is best known as a risk factor for Alzheimer's disease (AD). Consequently, there is
considerable research interest in understanding whether APOE-ε4 influences cognition in …

Importance In animal studies, brain-derived neurotrophic factor (BDNF) has been shown to
impact neuronal survival and function and improve synaptic plasticity and long-term …

Neurovascular dysfunction, including blood–brain barrier (BBB) breakdown and cerebral
blood flow (CBF) dysregulation and reduction, are increasingly recognized to contribute to …

As identified in previously published articles, including those published in this issue, the
detection of early cognitive impairment among older adult populations is worthy of …

Mixed dementia is the coexistence of Alzheimer's disease and cerebrovascular disease
(CVD) in the same demented patient. Currently, its diagnosis and treatment remains a …

Background: Alzheimer's disease (AD), the most common form of dementia, is a progressive
neurodegenerative disorder with interrelated molecular, physiological, anatomical …

Background Hippocampal atrophy is a well-known feature of Alzheimer's disease (AD), but
sensitivity and specificity of hippocampal volumetry are limited. Neuropathological studies …

Introduction Subjective cognitive decline (SCD) could indicate preclinical Alzheimer's
disease, but the existing literature is confounded by heterogeneous approaches to studying …