Mammalian fertilization is a fascinating process that leads to the formation of a new
individual. Eggs and sperm are complex cells that must meet at the appropriate time and …

BACKGROUND Klinefelter syndrome (KS) has been defined by sex chromosome
aneuploidies (classically 47, XXY) in the male patient. The peripubertal timeframe in KS …

Round spermatid injection (ROSI) results in a lower birth rate than intracytoplasmic sperm
injection, which has hampered its clinical application. Inefficient development of ROSI …

The world has recently experienced a decline in male reproductive (eg sperm counts and
motility) and metabolic (eg obesity and diabetes) health. Accumulated evidence from animal …

Retrieving spermatozoa from the testicles has been a great hope for patients with non-
obstructive azoospermia (NOA), but relevant methods have not yet been developed to the …

Fertility preservation via biobanking of testicular tissue retrieved from testicular biopsies is
now generally recommended for boys who need to undergo gonadotoxic treatment prior to …

Purpose Oocyte activation is a fundamental event at mammalian fertilization. In mammals,
this process is initiated by a series of characteristic calcium (Ca 2+) oscillations, induced by …

Over the past 40 years, since the publication of the original WHO Laboratory Manual for the
Examination and Processing of Human Semen, the laboratory methods used to evaluate …

Klinefelter syndrome (KS) is defined as the presence of one or more extra “X” chromosome
in a male patient. It affects approximately 1 in 600 newborn males and the most common …

Male germ cells undergo complex developmental processes eventually producing
spermatozoa through spermatogenesis, although the molecular mechanisms remain largely …