Granzyme B in inflammatory diseases: apoptosis, inflammation, extracellular matrix remodeling, epithelial-to-mesenchymal transition and fibrosis

F Velotti, I Barchetta, FA Cimini… - Frontiers in immunology, 2020 - frontiersin.org
Inflammation is strictly interconnected to anti-inflammatory mechanisms to maintain tissue
homeostasis. The disruption of immune homeostasis can lead to acute and chronic …

Emerging canonical and non-canonical roles of granzyme B in health and disease

E Tibbs, X Cao - Cancers, 2022 - mdpi.com
Simple Summary Granzyme B (GzmB) is a potent cytotoxic molecule that is used by cytotoxic
T lymphocytes and natural killer cells to kill targeted infected or cancerous cells. Since its …

Childhood, adolescent, and adulthood adiposity are associated with risk of PCOS: a Mendelian randomization study with meta-analysis

LJ Dobbie, B Pittam, SS Zhao, U Alam… - Human …, 2023 - academic.oup.com
STUDY QUESTION What is the influence of body composition during childhood,
adolescence, and adulthood, as well as metabolic parameters, on incident polycystic ovary …

Sick fat: the good and the bad of old and new circulating markers of adipose tissue inflammation

I Barchetta, FA Cimini, G Ciccarelli, MG Baroni… - Journal of …, 2019 - Springer
Adipose tissue (AT) is one of the largest endocrine organs contributing to metabolic
homeostasis. The functional pleiotropism of AT depends on its ability to secrete a large …

Effects and plasma proteomic analysis of GLP-1RA versus CPA/EE, in combination with metformin, on overweight PCOS women: a randomized controlled trial

M Liao, X Li, H Zhang, L Zhou, L Shi, W Li, R Shen… - Endocrine, 2024 - Springer
Purpose Polycystic ovary syndrome (PCOS) is characterized by reproductive dysfunctions
and metabolic disorders. This study aims to compare the therapeutic effectiveness of …

Dual roles of granzyme B

H Wang, Y Huang, J He, L Zhong… - Scandinavian Journal of …, 2021 - Wiley Online Library
Granzyme B (GZMB) was first identified as a factor that could eliminate cells such as tumour
cells and bacteria/virus‐infected cells. However, comprehensive studies conducted on …

The association between polycystic ovary syndrome and metabolic syndrome in adolescents: a systematic review and meta-analysis

L Fu, N Xie, F Qu, J Zhou, F Wang - Reproductive Sciences, 2023 - Springer
The association between polycystic ovary syndrome (PCOS) and metabolic syndrome
(MetS) is not widely recognized or properly assessed in adolescents. The aim of this study …

Association between insulin resistance and abnormal menstrual cycle in Chinese patients with polycystic ovary syndrome

J Niu, M Lu, B Liu - Journal of Ovarian Research, 2023 - Springer
Background Polycystic ovary syndrome (PCOS) is a common reproductive endocrine
disorder, which is characterized by insulin resistance (IR) and menstrual cycle disorders. IR …

Ovarian inflammatory mRNA profiles of a dehydroepiandrosterone plus high-fat diet-induced polycystic ovary syndrome mouse model

A Ullah, MJ Wang, JP Yang, EA Adu-Gyamfi… - Reproductive …, 2022 - Elsevier
Research question What is the expression pattern of inflammatory mRNA profiles of a
dehydroepiandrosterone (DHEA) plus high-fat diet (HFD)-induced polycystic ovary …

Cell death classification: A new insight based on molecular mechanisms

S Dehghan, N Kheshtchin, S Hassannezhad… - Experimental Cell …, 2023 - Elsevier
Cells tend to disintegrate themselves or are forced to undergo such destructive processes in
critical circumstances. This complex cellular function necessitates various mechanisms and …