Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic
activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly …

Objectives Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic lung disease characterized
by dry cough, fatigue, and progressive exertional dyspnea. Lung parenchyma and …

Macrophages (Mφ) are primary innate immune cells that exhibit diverse functions in
response to different pathogens or stimuli, and they are extensively involved in the …

Intercellular cross talk between cancer cells and stromal and immune cells is essential for
tumor progression and metastasis. Extracellular vesicles and particles (EVPs) are a …

In patients with diabetes, myocardial fibrosis may contribute to the pathogenesis of heart
failure and arrhythmogenesis, increasing ventricular stiffness and delaying conduction …

Background Patients with diabetes have an increased risk of nonunion and delayed union of
fractures. Macrophages have been shown as a key player in diabetic complications …

Cardiac fibrosis, a common pathophysiologic process in most heart diseases, refers to an
excess of extracellular matrix (ECM) deposition by cardiac fibroblasts (CFs), which can lead …

Rationale: After myocardial ischemic injury, improper phagocytic clearance of dying cardiac
cells and the ensuing lack of inflammation resolution results in adverse cardiac remodeling …

Following acute sciatic nerve crush injury (SNCI), inflammation and the improper phagocytic
clearance of dying Schwann cells (SCs) has effects on remodeling that lead to morbidity and …

Diabetes mellitus is one of the prime risk factors for cardiovascular complications and is
linked with high morbidity and mortality. Diabetic cardiomyopathy (DCM) often manifests as …