A vessel for change: endothelial dysfunction in cerebral small vessel disease
S Quick, J Moss, RM Rajani, A Williams - Trends in neurosciences, 2021 - cell.com
The blood vessels of the brain are lined with endothelial cells and it has been long known
that these help to regulate blood flow to the brain. However, there is increasing evidence …
that these help to regulate blood flow to the brain. However, there is increasing evidence …
The impact of cerebrovascular aging on vascular cognitive impairment and dementia
As human life expectancy rises, the aged population will increase. Aging is accompanied by
changes in tissue structure, often resulting in functional decline. For example, aging within …
changes in tissue structure, often resulting in functional decline. For example, aging within …
Gut microbes exacerbate systemic inflammation and behavior disorders in neurologic disease CADASIL
S Liu, X Men, Y Guo, W Cai, R Wu, R Gao, W Zhong… - Microbiome, 2023 - Springer
Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is a cerebral small vessel disease that carries mutations in …
leukoencephalopathy (CADASIL) is a cerebral small vessel disease that carries mutations in …
Notch and disease: a growing field
A Louvi, S Artavanis-Tsakonas - Seminars in cell & developmental biology, 2012 - Elsevier
Signals through the Notch receptors are used throughout development to control cellular
fate choices. Our intention here is to provide an overview of the involvement of Notch …
fate choices. Our intention here is to provide an overview of the involvement of Notch …
Protein aggregates containing wild-type and mutant NOTCH3 are major drivers of arterial pathology in CADASIL
N Dupré, F Gueniot, V Domenga-Denier… - The Journal of …, 2024 - Am Soc Clin Investig
Loss of arterial smooth muscle cells (SMCs) and abnormal accumulation of the extracellular
domain of the NOTCH3 receptor (Notch3ECD) are the 2 core features of CADASIL, a …
domain of the NOTCH3 receptor (Notch3ECD) are the 2 core features of CADASIL, a …
CADASIL from bench to bedside: disease models and novel therapeutic approaches
A Manini, L Pantoni - Molecular Neurobiology, 2021 - Springer
Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is a monogenic disease caused by NOTCH3 mutations …
leukoencephalopathy (CADASIL) is a monogenic disease caused by NOTCH3 mutations …
Translational models for vascular cognitive impairment: a review including larger species
Background Disease models are useful for prospective studies of pathology, identification of
molecular and cellular mechanisms, pre-clinical testing of interventions, and validation of …
molecular and cellular mechanisms, pre-clinical testing of interventions, and validation of …
Notch signalling in smooth muscle cells during development and disease
C Fouillade, M Monet-Leprêtre… - Cardiovascular …, 2012 - academic.oup.com
The Notch signalling pathway is a highly conserved cell–cell signalling mechanism that
plays a central role in the development and maturation of most vertebrate organs. In …
plays a central role in the development and maturation of most vertebrate organs. In …
Mouse models to study the effect of cardiovascular risk factors on brain structure and cognition
DI Bink, K Ritz, E Aronica… - Journal of Cerebral …, 2013 - journals.sagepub.com
Recent clinical data indicates that hemodynamic changes caused by cardiovascular
diseases such as atherosclerosis, heart failure, and hypertension affect cognition. Yet, the …
diseases such as atherosclerosis, heart failure, and hypertension affect cognition. Yet, the …
Patient-specific iPSC model of a genetic vascular dementia syndrome reveals failure of mural cells to stabilize capillary structures
J Kelleher, A Dickinson, S Cain, Y Hu, N Bates… - Stem Cell Reports, 2019 - cell.com
CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy) is the most common form of genetic stroke and vascular dementia …
leukoencephalopathy) is the most common form of genetic stroke and vascular dementia …