Ionic liquids (ILs) have been used as solvents or materials, or both, in many applications,
including pharmaceutics and medicine due to their exceptional properties consisting of the …

Lung cancer is one of the most rapidly growing malignancies in terms of morbidity and
mortality. Although traditional treatments have been used for more than 50 years, it is still far …

Background Numerous challenges are faced during formulation and biopharmaceutics of
newly developed drug molecules due to polymorphic conversion, poor bioavailability …

In this study, we used molecular simulations to design Ceritinib (CRT) co-amorphous
materials (CAMs) with concurrent improvement in solubility and bioavailability …

Abiraterone acetate, marketed as Zytiga®, is an antiandrogen medication used in the
treatment of prostate cancer. Abiraterone acetate is a BCS Class IV compound associated …

New therapeutics such as antisense oligonucleotides, small interfering RNA and peptide-
drug conjugates are taking great relevance in the pharmaceutical industry due to their …

Lipid-based formulations (LBF) are widely used by industry and accepted by the regulatory
authorities for oral drug delivery in the pharmaceutical and consumer healthcare market …

Oral administration is the most preferred route for drug administration in clinic. However, due
to unsatisfactory physicochemical properties of drugs and various physiological barriers, the …

Tyrosine kinase inhibitors (TKIs) can inhibit edema and neovascularization, such as in age-
related macular degeneration and diabetic retinopathy. However, their topical administration …

In this research, we utilized molecular simulations to create co-amorphous materials (CAMs)
of ceritinib (CRT) with the objective of improving its solubility and bioavailability. We …