Prostate cancer (PC) is one of the most common tumors and a leading cause of mortality
among men, resulting in~ 375 000 deaths annually worldwide. Various analytical methods …

In randomized phase III trials two anti-vascular endothelial growth factor (VEGF) approaches
have yielded survival benefit in patients with metastatic cancer. In one approach, the …

Background Recently, nanometer sized vesicles (termed exosomes) have been described
as a component of urine. Such vesicles may be a useful non-invasive source of markers in …

The role of VEGF during development and in pathology is well known, but its function in
normal adult tissues is poorly understood. Adverse effects associated with the use of anti …

Molecular markers have the potential to serve not only as prognostic factors but may be
targets for new therapeutic strategies and predictors of response in a range of cancers …

Purpose: A major difficulty in treating brain tumors is the lack of effective methods of
identifying novel or recurrent disease. In this study, we have evaluated the efficacy of urinary …

Standard chemotherapeutic drugs, when modified by the frequency and dose of
administration, can target angiogenesis. This approach is referred to as antiangiogenic …

The vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis and
vascular permeability. VEGF overexpression has been associated with advanced stage and …

Purpose: To determine the maximum tolerated dose (MTD) dose-limiting toxicity, and
pharmacokinetic and pharmacodynamic profile of TKI258 (formerly CHIR-258) …

Although still in very early stages of clinical development, the combination of
antiangiogenics with contemporary chemoradiotherapy regimens has emerged as a feasible …