Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …

Patients who have recovered from coronavirus disease 2019 (COVID-19) infection may
experience chronic fatigue when exercising, despite no obvious heart or lung abnormalities …

Cognitive dysfunction is often reported in patients with post-coronavirus disease 2019
(COVID-19) syndrome, but its underlying mechanisms are not completely understood …

The COVID-19 pandemic was caused by the recently emerged β-coronavirus SARS-CoV-2.
SARS-CoV-2 has had a catastrophic impact, resulting in nearly 7 million fatalities worldwide …

Highlights•SARS-CoV-2 infection in vitro triggers activation of the NLRP3
inflammasome.•The NLRP3 is activated in mice infected with SARS-CoV-2 and in the lungs …

Inflammasomes are molecular scaffolds that are activated by damage-associated and
pathogen-associated molecular patterns and form a key element of innate immune …

Highlights•Human coronaviruses use distinctand similar strategies to counteract innate
defenses.•Insights from SARS-CoV-2 will inspire research on endemic and epidemic …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a contagious respiratory
virus that is the cause of the coronavirus disease 2019 (COVID-19) pandemic which has …

Immunothrombosis—immune-mediated activation of coagulation—is protective against
pathogens, but excessive immunothrombosis can result in pathological thrombosis and …

Coronavirus disease 2019 (COVID-19) increases the risk of thromboembolic events,
especially in patients with severe infections requiring intensive care and cardiorespiratory …