The study of brain plasticity has tended to focus on the synapse, where well-described
activity-dependent mechanisms are known to play a key role in learning and memory …

The nodes of Ranvier have clustered Na+ and K+ channels necessary for rapid and efficient
axonal action potential conduction. However, detailed mechanisms of channel clustering …

Neurons in the developing brain undergo extensive structural refinement as nascent circuits
adopt their mature form. This physical transformation of neurons is facilitated by the …

Oligodendrocyte precursors (OPs) continue to proliferate and generate myelinating
oligodendrocytes (OLs) well into adulthood. It is not known whether adult-born OLs …

Oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), and
astrocytes constitute macroglia. This review deals with the recent progress related to the …

Studies of activity-driven nervous system plasticity have primarily focused on the gray matter.
However, MRI-based imaging studies have shown that white matter, primarily composed of …

Platelet-derived growth factor α receptor (PDGFRA)/NG2–expressing glia are distributed
throughout the adult CNS. They are descended from oligodendrocyte precursors (OLPs) in …

Glial progenitor cells of the developing CNS committed to the oligodendrocyte lineage
(OPCs) express the chondroitin sulfate proteoglycan, NG2. A proportion of OPCs fail to …

Spinal cord injuries (SCIs) result in devastating lifelong disability for patients and their
families. The initial mechanical trauma is followed by a damaging secondary injury cascade …

Multiple sclerosis (MS) is characterized by multifocal loss of myelin, oligodendrocytes, and
axons. Potential MS therapies include enhancement of remyelination by transplantation or …