Recent insights into the roles of circular RNAs in human brain development and neurologic diseases

S Najafi, SMA Zarch, J Majidpoor, S Pordel… - International Journal of …, 2023 - Elsevier
Circular RNAs (circRNAs) are a novel class of non-coding RNAs. They are single-stranded
RNA transcripts characterized with a closed loop structure making them resistant to …

The potential of using blood circular RNA as liquid biopsy biomarker for human diseases

G Wen, T Zhou, W Gu - Protein & cell, 2021 - academic.oup.com
Circular RNA (circRNA) is a novel class of single-stranded RNAs with a closed loop
structure. The majority of circRNAs are formed by a back-splicing process in pre-mRNA …

Epigenetic modification mechanisms involved in keloid: current status and prospect

W Lv, Y Ren, K Hou, W Hu, Y Yi, M Xiong, M Wu… - Clinical …, 2020 - Springer
Keloid, a common dermal fibroproliferative disorder, is benign skin tumors characterized by
the aggressive fibroblasts proliferation and excessive accumulation of extracellular matrix …

Circular RNA cia-MAF drives self-renewal and metastasis of liver tumor-initiating cells via transcription factor MAFF

Z Chen, T Lu, L Huang, Z Wang, Z Yan… - The Journal of …, 2021 - Am Soc Clin Investig
Liver tumor-initiating cells (TICs) are involved in liver tumorigenesis, metastasis, drug
resistance, and relapse, but the regulatory mechanisms of liver TICs are largely unknown …

Exosomal hsa_circRNA_104484 and hsa_circRNA_104670 may serve as potential novel biomarkers and therapeutic targets for sepsis

C Tian, J Liu, X Di, S Cong, M Zhao, K Wang - Scientific Reports, 2021 - nature.com
In order to explore the role of exosomal circRNAs in the occurrence and development of
sepsis, we looked for potential diagnostic markers to accurately identify sepsis and to lay a …

rtcisE2F promotes the self-renewal and metastasis of liver tumor-initiating cells via N6-methyladenosine-dependent E2F3/E2F6 mRNA stability

Z Chen, L Huang, K Wang, L Zhang, X Zhong… - Science China Life …, 2022 - Springer
Liver cancer is highly heterogeneous, and the tumor tissue harbors a variety of cell types.
Liver tumor initiating cells (TICs) well contribute to tumor heterogeneity and account for …

Circular RNAs in inflammatory bowel disease

J Lun, J Guo, M Yu, H Zhang, J Fang - Frontiers in Immunology, 2023 - frontiersin.org
Inflammatory bowel disease (IBD) is a term encompassing a few chronic inflammatory
disorders that leads to damage of the intestinal tract. Although much progress has been …

Circular RNA circZNF532 facilitates angiogenesis and inflammation in diabetic retinopathy via regulating miR-1243/CARM1 axis

T Wang, C Li, M Shi, S Zhou, J Chen… - Diabetology & metabolic …, 2022 - Springer
Background Diabetic retinopathy (DR) is a serious complication of diabetes. Numerous
reports have validated that circular RNAs (circRNAs) participate in DR progression. This …

Circular RNAs: their role in the pathogenesis and orchestration of breast cancer

X He, T Xu, W Hu, Y Tan, D Wang, Y Wang… - Frontiers in Cell and …, 2021 - frontiersin.org
As one of the most frequently occurring malignancies in women, breast cancer (BC) is still
an enormous threat to women all over the world. The high mortality rates in BC patients are …

Emerging roles of circular RNAs in systemic lupus erythematosus

X Wang, R Ma, W Shi, Z Wu, Y Shi - Molecular Therapy-Nucleic Acids, 2021 - cell.com
Circular RNAs (circRNAs) are a class of non-coding RNAs with covalently closed single-
stranded structures lacking 5′–3′ polarity and a polyadenine tail. Over recent years, a …