Optical tweezers have become the method of choice in single-molecule manipulation
studies. In this Primer, we first review the physical principles of optical tweezers and the …

Non-homologous DNA end joining (NHEJ) is the predominant repair mechanism of any type
of DNA double-strand break (DSB) during most of the cell cycle and is essential for the …

DNA double-strand breaks (DSBs) are the most dangerous type of DNA damage because
they can result in the loss of large chromosomal regions. In all mammalian cells, DSBs that …

Nonhomologous DNA end-joining (NHEJ) is the predominant double-strand break (DSB)
repair pathway throughout the cell cycle and accounts for nearly all DSB repair outside of …

DNA is the source of genetic information, and preserving its integrity is essential in order to
sustain life. The genome is continuously threatened by different types of DNA lesions, such …

DNA double-strand breaks pose a serious threat to genome stability. In vertebrates, these
breaks are predominantly repaired by nonhomologous end joining (NHEJ), which pairs DNA …

Oral squamous cell carcinoma (OSCC), the eighth most prevalent cancer in the world, arises
from the interaction of multiple factors including tobacco, alcohol consumption, and betel …

Cancer genome sequencing has identified chromothripsis, a complex class of structural
genomic rearrangements involving the apparent shattering of an individual chromosome …

Non-homologous end joining (NHEJ) is one of two critical mechanisms utilized in humans to
repair DNA double-strand breaks (DSBs). Unrepaired or incorrect repair of DSBs can lead to …

DNA double-strand breaks are the most dangerous type of DNA damage and, if not repaired
correctly, can lead to cancer. In humans, Ku70/80 recognizes DNA broken ends and recruits …