It is essential to acknowledge the efforts made thus far to manage or eliminate various
disease burden faced by humankind. However, the rising global trends of the so-called …

Introduction: Docking and structure-based virtual screening (VS) have been standard
approaches in structure-based design for over two decades. However, our understanding of …

Diabetes mellitus is a worldwide impacting disorder and the ratio through which the number
of diabetic patients had increased worldwide, puts medical professionals to serious stress …

Diabetes mellitus is a metabolic disease that can lead to high morbidity, mortality and long-
term complications. Available treatment strategies, which are mainly based on treating …

Glucokinase is a key enzyme which converts glucose into glucose‐6‐phosphate in the liver
and pancreatic cells of the human. In the liver, glucokinase promotes the synthesis of …

Abstract Glutamic-oxaloacetic transaminase 1 (GOT1) regulates cellular metabolism through
coordinating the utilization of carbohydrates and amino acids to meet nutrient requirements …

A series of hetero-substituted sulphonamido-benzamide derivatives which can activate
glucokinase (GK) were synthesized and screened in-vitro using Human GK activation assay …

Pancreatic ductal adenocarcinoma (PDAC) is a fatal malignant tumor whose effective
treatment has not been found. The redox state and proliferative activity of PDAC cells are …

Background: Over the past decades, the development and use of an array of prescription
medications have considerably improved the clinical management of type 2 diabetes …

Polymorphism rs13266634 in SLC30A8 causes abnormal synthesis, maturation and
secretion of insulin, resulting in decrease in efficiency of glucose metabolism and diabetes …