The amyotrophic lateral sclerosis exposome: recent advances and future directions
Amyotrophic lateral sclerosis (ALS) is a fatal disease of motor neuron degeneration with
typical survival of only 2–5 years from diagnosis. The causes of ALS are multifactorial …
typical survival of only 2–5 years from diagnosis. The causes of ALS are multifactorial …
Metabolomic epidemiology offers insights into disease aetiology
Metabolomic epidemiology is the high-throughput study of the relationship between
metabolites and health-related traits. This emerging and rapidly growing field has improved …
metabolites and health-related traits. This emerging and rapidly growing field has improved …
[HTML][HTML] The exposome and liver disease-how environmental factors affect liver health
R Barouki, M Samson, EB Blanc, M Colombo… - Journal of …, 2023 - Elsevier
Since the initial development of the exposome concept, much effort has been devoted to the
characterisation of the exposome through analytical, epidemiological, and toxicological …
characterisation of the exposome through analytical, epidemiological, and toxicological …
Association between organophosphate ester exposure and insulin resistance with glycometabolic disorders among older chinese adults 60–69 years of age …
Background: Organophosphate esters (OPEs) are common endocrine-disrupting chemicals,
and OPE exposure may be associated with type 2 diabetes (T2D). However, greater …
and OPE exposure may be associated with type 2 diabetes (T2D). However, greater …
The exposome and toxicology: a win–win collaboration
R Barouki, K Audouze, C Becker, L Blaha… - Toxicological …, 2022 - academic.oup.com
The development of the exposome concept has been one of the hallmarks of environmental
and health research for the last decade. The exposome encompasses the life course …
and health research for the last decade. The exposome encompasses the life course …
Charting the landscape of the environmental exposome
The exposome depicts the total exposures in the lifetime of an organism. Human exposome
comprises exposures from environmental and humanistic sources. Biological, chemical, and …
comprises exposures from environmental and humanistic sources. Biological, chemical, and …
[HTML][HTML] AOP-helpFinder 2.0: integration of an event-event searches module
T Jaylet, T Coustillet, F Jornod… - Environment …, 2023 - Elsevier
To support the use of alternative methods in regulatory assessment of chemical risks, the
concept of adverse outcome pathway (AOP) constitutes an important toxicological tool. AOP …
concept of adverse outcome pathway (AOP) constitutes an important toxicological tool. AOP …
A critical review on the opportunity to use placenta and innovative biomonitoring methods to characterize the prenatal chemical exposome
T Contini, R Béranger, L Multigner… - Environmental …, 2023 - ACS Publications
Adverse effects associated with chemical exposures during pregnancy include several
developmental and reproductive disorders. However, considering the tens of thousands of …
developmental and reproductive disorders. However, considering the tens of thousands of …
Toward a more holistic approach to the study of exposures and child outcomes
Aim: The current work was designed to demonstrate the application of the exposome
framework in examining associations between exposures and children's long-term …
framework in examining associations between exposures and children's long-term …
Adopting Mechanistic Molecular Biology Approaches in Exposome Research for Causal Understanding
AL Foreman, B Warth, EVS Hessel… - Environmental …, 2024 - ACS Publications
Through investigating the combined impact of the environmental exposures experienced by
an individual throughout their lifetime, exposome research provides opportunities to …
an individual throughout their lifetime, exposome research provides opportunities to …