Prion diseases range from being highly infectious, for example scrapie and CWD which
show facile transmission between susceptible individuals, to showing negligible horizontal …

Importance Parkinson disease (PD) is a highly prevalent and incurable neurodegenerative
disease associated with the accumulation of misfolded α-synuclein (αSyn) aggregates. An …

The ability of abnormal TSE-associated forms of PrP to seed the formation of amyloid fibrils
from recombinant PrPSen has served as the basis for several relatively rapid and highly …

A major problem for the effective diagnosis and management of prion diseases is the lack of
rapid high-throughput assays to measure low levels of prions. Such measurements have …

Infectious prions containing the pathogenic conformer of the mammalian prion protein
(PrPSc) can be produced de novo from a mixture of the normal conformer (PrPC) with RNA …

Key to understanding the epidemiology and pathogenesis of prion diseases, including
chronic wasting disease (CWD) of cervids, is determining the mode of transmission from one …

ABSTRACT A key challenge in managing transmissible spongiform encephalopathies
(TSEs) or prion diseases in medicine, agriculture, and wildlife biology is the development of …

Prions are proteinaceous infectious agents responsible for the transmission of prion
diseases. The lack of a procedure for cultivating prions in the laboratory has been a major …

Prion diseases are infectious neurodegenerative disorders that affect humans and animals
and that result from the conversion of normal prion protein (PrP C) into the misfolded prion …

The emergence of variant Creutzfeldt Jakob Disease (vCJD) is considered a likely
consequence of human dietary exposure to Bovine Spongiform Encephalopathy (BSE) …