Antibodies to combat viral infections: development strategies and progress

G Pantaleo, B Correia, C Fenwick, VS Joo… - Nature Reviews Drug …, 2022 - nature.com
Monoclonal antibodies (mAbs) are appealing as potential therapeutics and prophylactics for
viral infections owing to characteristics such as their high specificity and their ability to …

Antibody structure and function: the basis for engineering therapeutics

ML Chiu, DR Goulet, A Teplyakov, GL Gilliland - Antibodies, 2019 - mdpi.com
Antibodies and antibody-derived macromolecules have established themselves as the
mainstay in protein-based therapeutic molecules (biologics). Our knowledge of the structure …

Beyond binding: antibody effector functions in infectious diseases

LL Lu, TJ Suscovich, SM Fortune, G Alter - Nature Reviews Immunology, 2018 - nature.com
Antibodies play an essential role in host defence against pathogens by recognizing
microorganisms or infected cells. Although preventing pathogen entry is one potential …

Nanophotonic biosensors harnessing van der Waals materials

SH Oh, H Altug, X Jin, T Low, SJ Koester… - Nature …, 2021 - nature.com
Low-dimensional van der Waals (vdW) materials can harness tightly confined polaritonic
waves to deliver unique advantages for nanophotonic biosensing. The reduced …

Beyond natural antibodies: the power of in vitro display technologies

ARM Bradbury, S Sidhu, S Dübel, J McCafferty - Nature biotechnology, 2011 - nature.com
In vitro display technologies, best exemplified by phage and yeast display, were first
described for the selection of antibodies some 20 years ago. Since then, many antibodies …

Selecting and screening recombinant antibody libraries

HR Hoogenboom - Nature biotechnology, 2005 - nature.com
During the past decade several display methods and other library screening techniques
have been developed for isolating monoclonal antibodies (mAbs) from large collections of …

Identification and multidimensional optimization of an asymmetric bispecific IgG antibody mimicking the function of factor VIII cofactor activity

Z Sampei, T Igawa, T Soeda, Y Okuyama-Nishida… - PloS one, 2013 - journals.plos.org
In hemophilia A, routine prophylaxis with exogenous factor VIII (FVIII) requires frequent
intravenous injections and can lead to the development of anti-FVIII alloantibodies (FVIII …

Therapeutic antibodies for human diseases at the dawn of the twenty-first century

OH Brekke, I Sandlie - Nature reviews Drug discovery, 2003 - nature.com
Antibodies are highly specific, naturally evolved molecules that recognize and eliminate
pathogenic and disease antigens. The past 30 years of antibody research have hinted at the …

Engineered antibodies

PJ Hudson, C Souriau - Nature medicine, 2003 - nature.com
Engineered antibodies now represent over 30% of biopharmaceuticals in clinical trials, as
highlighted by recent approvals from the US Food and Drug Administration. Recombinant …

MF59 adjuvant enhances diversity and affinity of antibody-mediated immune response to pandemic influenza vaccines

S Khurana, N Verma, JW Yewdell, AK Hilbert… - Science translational …, 2011 - science.org
Oil-in-water adjuvants have been shown to improve immune responses against pandemic
influenza vaccines as well as reduce the effective vaccine dose, increasing the number of …