Antibodies to combat viral infections: development strategies and progress
G Pantaleo, B Correia, C Fenwick, VS Joo… - Nature Reviews Drug …, 2022 - nature.com
Monoclonal antibodies (mAbs) are appealing as potential therapeutics and prophylactics for
viral infections owing to characteristics such as their high specificity and their ability to …
viral infections owing to characteristics such as their high specificity and their ability to …
Antibody structure and function: the basis for engineering therapeutics
ML Chiu, DR Goulet, A Teplyakov, GL Gilliland - Antibodies, 2019 - mdpi.com
Antibodies and antibody-derived macromolecules have established themselves as the
mainstay in protein-based therapeutic molecules (biologics). Our knowledge of the structure …
mainstay in protein-based therapeutic molecules (biologics). Our knowledge of the structure …
Beyond binding: antibody effector functions in infectious diseases
LL Lu, TJ Suscovich, SM Fortune, G Alter - Nature Reviews Immunology, 2018 - nature.com
Antibodies play an essential role in host defence against pathogens by recognizing
microorganisms or infected cells. Although preventing pathogen entry is one potential …
microorganisms or infected cells. Although preventing pathogen entry is one potential …
Nanophotonic biosensors harnessing van der Waals materials
Low-dimensional van der Waals (vdW) materials can harness tightly confined polaritonic
waves to deliver unique advantages for nanophotonic biosensing. The reduced …
waves to deliver unique advantages for nanophotonic biosensing. The reduced …
Beyond natural antibodies: the power of in vitro display technologies
In vitro display technologies, best exemplified by phage and yeast display, were first
described for the selection of antibodies some 20 years ago. Since then, many antibodies …
described for the selection of antibodies some 20 years ago. Since then, many antibodies …
Selecting and screening recombinant antibody libraries
HR Hoogenboom - Nature biotechnology, 2005 - nature.com
During the past decade several display methods and other library screening techniques
have been developed for isolating monoclonal antibodies (mAbs) from large collections of …
have been developed for isolating monoclonal antibodies (mAbs) from large collections of …
Identification and multidimensional optimization of an asymmetric bispecific IgG antibody mimicking the function of factor VIII cofactor activity
Z Sampei, T Igawa, T Soeda, Y Okuyama-Nishida… - PloS one, 2013 - journals.plos.org
In hemophilia A, routine prophylaxis with exogenous factor VIII (FVIII) requires frequent
intravenous injections and can lead to the development of anti-FVIII alloantibodies (FVIII …
intravenous injections and can lead to the development of anti-FVIII alloantibodies (FVIII …
Therapeutic antibodies for human diseases at the dawn of the twenty-first century
OH Brekke, I Sandlie - Nature reviews Drug discovery, 2003 - nature.com
Antibodies are highly specific, naturally evolved molecules that recognize and eliminate
pathogenic and disease antigens. The past 30 years of antibody research have hinted at the …
pathogenic and disease antigens. The past 30 years of antibody research have hinted at the …
Engineered antibodies
PJ Hudson, C Souriau - Nature medicine, 2003 - nature.com
Engineered antibodies now represent over 30% of biopharmaceuticals in clinical trials, as
highlighted by recent approvals from the US Food and Drug Administration. Recombinant …
highlighted by recent approvals from the US Food and Drug Administration. Recombinant …
MF59 adjuvant enhances diversity and affinity of antibody-mediated immune response to pandemic influenza vaccines
S Khurana, N Verma, JW Yewdell, AK Hilbert… - Science translational …, 2011 - science.org
Oil-in-water adjuvants have been shown to improve immune responses against pandemic
influenza vaccines as well as reduce the effective vaccine dose, increasing the number of …
influenza vaccines as well as reduce the effective vaccine dose, increasing the number of …