The emergence of multi-drug-resistant bacteria is threatening to human health and life
around the world. In particular, methicillin-resistant Staphylococcus aureus (MRSA) causes …

A novel type of coumarin thiazoles as unique multi-targeting antimicrobial agents were
developed through four steps including cyclization, nucleophilic substitution and …

Main observation and conclusion The limit ability of traditional antibiotics to treat drug
resistant bacteria calls for new therapeutic alternatives. A class of unique sulfanilamide …

This work explored a novel type of potential multi-targeting antimicrobial three-component
sulfanilamide hybrids in combination of pyrimidine and azoles. The hybridized target …

Replacement of the n-butylphenyl moiety in the lipophilic part of the previously reported
arylthiazole antibiotics with naphthyl ring amended its activity against vancomycin resistant …

Candida species are a leading source of healthcare infections globally. The limited number
of antifungal drugs combined with the isolation of Candida species, namely C. albicans and …

The narrow antibacterial spectrum of phenylthiazole antibiotics was expanded by replacing
central thiazole with a pyrazole ring while maintaining its other pharmacophoric features …

A set of structurally related diphenylurea derivatives bearing aminoguanidine moiety were
synthesized, and their antibacterial activity was assessed against a panel of multi-drug …

The increasing emergence of antibiotic-resistant bacterial pathogens calls for additional
urgency in the development of new antibacterial candidates. N-Phenyl-2-aminothiazoles are …

A new class of alkynyl isoquinoline antibacterial compounds, synthesized via Sonogashira
coupling, with strong bactericidal activity against a plethora of Gram-positive bacteria …