The Indonesian archipelago is home to the second largest biodiversity in the world and is
inhabited by more than 300 ethnic groups with a total population of more than 270 million …

Terpenes are made of the isoprene unit (C 5), and along with their derivatives, terpenoids,
they are widely distributed in plants as active ingredients involved in anti-inflammation, anti …

Tamoxifen is the most frequently used anti-estrogen adjuvant treatment for estrogen receptor-
positive breast cancer. However, it is associated with an increased risk of several serious …

Estrogen receptor alpha (ERα) acts as the transcription factor and the main therapeutic
target against breast cancer. One of the compounds that has been shown to act as an ERα is …

Inflamasi merupakan suatu respon dari tubuh terhadap adanya cedera maupun infeksi yang
ditandai dengan timbulnya kemerahan, demam, bengkak, nyeri dan hilangnya fungsi …

Background The fruits of P. macrocarpa have long been used as a traditional Malay
medicinal herb for hundreds of years. Intraperitoneal (ip) injection of streptozotocin (STZ)(65 …

The estrogen receptor α (ERα) is an important biological target mediating 17β-estradiol
driven breast cancer (BC) development. Aiming to develop innovative drugs against BC …

α-Mangostin is one of the secondary metabolites in mangosteen pericarp, which has been
reported to have anti-breast cancer activity. In our previous study, three α-mangostin …

A series of 2, 3, 4-triaryl-substituted 1, 2, 4-oxadiazole-5-ones have been prepared as fixed-
ring analogues of tamoxifen (TAM), a drug inhibitor of Estradiol Receptor (ER) used in breast …

Abstract Ethnopharmacological relevance Phaleria macrocarpa (Scheff) Boerl, is a well-
known folk medicinal plant in Indonesia. Traditionally, P. macrocarpa has been used to …