Glutathione: new roles in redox signaling for an old antioxidant

K Aquilano, S Baldelli, MR Ciriolo - Frontiers in pharmacology, 2014 - frontiersin.org
The physiological roles played by the tripeptide glutathione have greatly advanced over the
past decades superimposing the research on free radicals, oxidative stress and, more …

Redox-modulating agents in the treatment of viral infections

P Checconi, M De Angelis, ME Marcocci… - International Journal of …, 2020 - mdpi.com
Viruses use cell machinery to replicate their genome and produce viral proteins. For this
reason, several intracellular factors, including the redox state, might directly or indirectly …

Infectious agents and neurodegeneration

G De Chiara, ME Marcocci, R Sgarbanti, L Civitelli… - Molecular …, 2012 - Springer
A growing body of epidemiologic and experimental data point to chronic bacterial and viral
infections as possible risk factors for neurodegenerative diseases, including Alzheimer's …

Development of metal complexes for treatment of coronaviruses

HMA El-Lateef, T El-Dabea, MM Khalaf… - International Journal of …, 2022 - mdpi.com
Coronavirus disease (SARS-CoV-2) is a global epidemic. This pandemic, which has been
linked to high rates of death, has forced some countries throughout the world to implement …

N-acetyl-L-cysteine (NAC) inhibits virus replication and expression of pro-inflammatory molecules in A549 cells infected with highly pathogenic H5N1 influenza A virus

J Geiler, M Michaelis, P Naczk, A Leutz… - Biochemical …, 2010 - Elsevier
The antioxidant N-acetyl-l-cysteine (NAC) had been shown to inhibit replication of seasonal
human influenza A viruses. Here, the effects of NAC on virus replication, virus-induced pro …

p53 orchestrates the PGC-1α-mediated antioxidant response upon mild redox and metabolic imbalance

K Aquilano, S Baldelli, B Pagliei… - Antioxidants & redox …, 2013 - liebertpub.com
Aims: The transcriptional coactivator peroxisome proliferator-activated receptor-γ coactivator-
1 α (PPARGC1A or PGC-1α) is a powerful controller of cell metabolism and assures the …

Antiviral strategies against influenza virus: towards new therapeutic approaches

A Loregian, B Mercorelli, G Nannetti… - Cellular and molecular …, 2014 - Springer
Influenza viruses are major human pathogens responsible for respiratory diseases affecting
millions of people worldwide and characterized by high morbidity and significant mortality …

Influenza virus replication in lung epithelial cells depends on redox‐sensitive pathways activated by NOX4‐derived ROS

D Amatore, R Sgarbanti, K Aquilano… - Cellular …, 2015 - Wiley Online Library
An overproduction of reactive oxygen species (ROS) mediated by NADPH oxidase 2 (NOX2)
has been related to airway inflammation typical of influenza infection. Virus‐induced …

Influenza virus infections and cellular kinases

R Meineke, GF Rimmelzwaan, H Elbahesh - Viruses, 2019 - mdpi.com
Influenza A viruses (IAVs) are a major cause of respiratory illness and are responsible for
yearly epidemics associated with more than 500,000 annual deaths globally. Novel IAVs …

Redox control in the pathophysiology of influenza virus infection

KK Chen, M Minakuchi, K Wuputra, CC Ku, JB Pan… - BMC microbiology, 2020 - Springer
Triggered in response to external and internal ligands in cells and animals, redox
homeostasis is transmitted via signal molecules involved in defense redox mechanisms …