ATP-dependent chromatin remodeling during mammalian development
SK Hota, BG Bruneau - Development, 2016 - journals.biologists.com
Precise gene expression ensures proper stem and progenitor cell differentiation, lineage
commitment and organogenesis during mammalian development. ATP-dependent …
commitment and organogenesis during mammalian development. ATP-dependent …
Solid tumours hijack the histone variant network
Cancer is a complex disease characterized by loss of cellular homeostasis through genetic
and epigenetic alterations. Emerging evidence highlights a role for histone variants and their …
and epigenetic alterations. Emerging evidence highlights a role for histone variants and their …
Transcriptional pause sites delineate stable nucleosome-associated premature polyadenylation suppressed by U1 snRNP
Regulation of RNA polymerase II (Pol II) elongation is a critical step in gene regulation.
Here, we report that U1 snRNP recognition and transcription pausing at stable nucleosomes …
Here, we report that U1 snRNP recognition and transcription pausing at stable nucleosomes …
Acquired tissue-specific promoter bivalency is a basis for PRC2 necessity in adult cells
U Jadhav, K Nalapareddy, M Saxena, NK O'Neill… - Cell, 2016 - cell.com
Bivalent promoters in embryonic stem cells (ESCs) carry methylation marks on two lysine
residues, K4 and K27, in histone3 (H3). K4me2/3 is generally considered to promote …
residues, K4 and K27, in histone3 (H3). K4me2/3 is generally considered to promote …
The impact of SWI/SNF and NuRD inactivation on gene expression is tightly coupled with levels of RNA polymerase II occupancy at promoters
S Pundhir, J Su, M Tapia, AM Hansen… - Genome …, 2023 - genome.cshlp.org
SWI/SNF and NuRD are protein complexes that antagonistically regulate DNA accessibility.
However, repression of their activities often leads to unanticipated changes in target gene …
However, repression of their activities often leads to unanticipated changes in target gene …
The histone variant H2A. Z in yeast is almost exclusively incorporated into the+ 1 nucleosome in the direction of transcription
DN Bagchi, AM Battenhouse, D Park… - Nucleic acids …, 2020 - academic.oup.com
Transcription start sites (TSS) in eukaryotes are characterized by a nucleosome-depleted
region (NDR), which appears to be flanked upstream and downstream by strongly …
region (NDR), which appears to be flanked upstream and downstream by strongly …
[HTML][HTML] H2A. Z: a molecular rheostat for transcriptional control
The replacement of nucleosomal H2A with the histone variant H2A. Z is critical for regulating
DNA-mediated processes across eukaryotes and for early development of multicellular …
DNA-mediated processes across eukaryotes and for early development of multicellular …
Histone variants H2A. Z and H3. 3 coordinately regulate PRC2-dependent H3K27me3 deposition and gene expression regulation in mES cells
Background The hierarchical organization of eukaryotic chromatin plays a central role in
gene regulation, by controlling the extent to which the transcription machinery can access …
gene regulation, by controlling the extent to which the transcription machinery can access …
Genome-wide chromatin accessibility is restricted by ANP32E
KE Murphy, FW Meng, CE Makowski… - Nature …, 2020 - nature.com
Genome-wide chromatin state underlies gene expression potential and cellular function.
Epigenetic features and nucleosome positioning contribute to the accessibility of DNA, but …
Epigenetic features and nucleosome positioning contribute to the accessibility of DNA, but …
A new link between transcriptional initiation and pre-mRNA splicing: The RNA binding histone variant H2A. B
The replacement of histone H2A with its variant forms is critical for regulating all aspects of
genome organisation and function. The histone variant H2A. B appeared late in evolution …
genome organisation and function. The histone variant H2A. B appeared late in evolution …