Clinical application status of articular cartilage regeneration techniques: tissue‐engineered cartilage brings new hope

S Jiang, W Guo, G Tian, X Luo, L Peng… - Stem Cells …, 2020 - Wiley Online Library
Hyaline articular cartilage lacks blood vessels, lymphatics, and nerves and is characterised
by limited self‐repair ability following injury. Traditional techniques of articular cartilage …

Emergence of scaffold-free approaches for tissue engineering musculoskeletal cartilages

GD DuRaine, WE Brown, JC Hu… - Annals of biomedical …, 2015 - Springer
This review explores scaffold-free methods as an additional paradigm for tissue
engineering. Musculoskeletal cartilages—for example articular cartilage, meniscus …

[HTML][HTML] Regenerative approaches for cartilage repair in the treatment of osteoarthritis

MH Li, R Xiao, JB Li, Q Zhu - Osteoarthritis and cartilage, 2017 - Elsevier
Osteoarthritis (OA) as a debilitating affliction of joints currently affects millions of people and
remains an unsolved problem. The disease involves multiple cellular and molecular …

Anatomically shaped tissue-engineered cartilage with tunable and inducible anticytokine delivery for biological joint resurfacing

FT Moutos, KA Glass, SA Compton… - Proceedings of the …, 2016 - National Acad Sciences
Biological resurfacing of entire articular surfaces represents an important but challenging
strategy for treatment of cartilage degeneration that occurs in osteoarthritis. Not only does …

Gelatin scaffolds with controlled pore structure and mechanical property for cartilage tissue engineering

S Chen, Q Zhang, T Nakamoto… - … Engineering Part C …, 2016 - liebertpub.com
Engineering of cartilage tissue in vitro using porous scaffolds and chondrocytes provides a
promising approach for cartilage repair. However, nonuniform cell distribution and …

[HTML][HTML] Engineered cartilage utilizing fetal cartilage-derived progenitor cells for cartilage repair

DY Park, BH Min, SR Park, HJ Oh, MD Truong… - Scientific Reports, 2020 - nature.com
The aim of this study was to develop a fetal cartilage-derived progenitor cell (FCPC) based
cartilage gel through self-assembly for cartilage repair surgery, with clinically useful …

In vitro and in vivo evaluation of the developed PLGA/HAp/Zein scaffolds for bone-cartilage interface regeneration

YX Lin, ZY Ding, XB Zhou, ST Li, XIE De Ming… - Biomedical and …, 2015 - Elsevier
Objective To investigate the effect of electronspun PLGA/HAp/Zein scaffolds on the repair of
cartilage defects. Methods The PLGA/HAp/Zein composite scaffolds were fabricated by …

Thyroxine increases collagen type II expression and accumulation in scaffold-free tissue-engineered articular cartilage

GA Whitney, TJ Kean, RJ Fernandes… - … Engineering Part A, 2018 - liebertpub.com
Low collagen accumulation in the extracellular matrix is a pressing problem in cartilage
tissue engineering, leading to a low collagen-to-glycosaminoglycan (GAG) ratio and poor …

Strategies for improving the repair of focal cartilage defects

P Abdel-Sayed, DP Pioletti - Nanomedicine, 2015 - Taylor & Francis
Articular cartilage, together with skin, was predicted to be one of the first tissues to be
successfully engineered. However cartilage repair remains nowadays still elusive, as we are …

Functional tissue engineering of articular cartilage for biological joint resurfacing—The 2021 Elizabeth Winston Lanier Kappa Delta Award

F Guilak, BT Estes, FT Moutos - Journal of Orthopaedic …, 2022 - Wiley Online Library
Biological resurfacing of entire articular surfaces represents a challenging strategy for the
treatment of cartilage degeneration that occurs in osteoarthritis. Not only does this approach …