Ultrasound mediated delivery of drugs and genes to solid tumors

V Frenkel - Advanced drug delivery reviews, 2008 - Elsevier
It has long been shown that therapeutic ultrasound can be used effectively to ablate solid
tumors, and a variety of cancers are presently being treated in the clinic using these types of …

Image-guided ultrasound phased arrays are a disruptive technology for non-invasive therapy

K Hynynen, RM Jones - Physics in Medicine & Biology, 2016 - iopscience.iop.org
Focused ultrasound offers a non-invasive way of depositing acoustic energy deep into the
body, which can be harnessed for a broad spectrum of therapeutic purposes, including …

MRI-guided focused ultrasound treatments

K Hynynen - Ultrasonics, 2010 - Elsevier
Focused ultrasound (FUS) allows noninvasive focal delivery of energy deep into soft tissues.
The focused energy can be used to modify and eliminate tissue for therapeutic purposes …

Clinical performance and future potential of magnetic resonance thermometry in hyperthermia

TV Feddersen, JA Hernandez-Tamames, M Franckena… - Cancers, 2020 - mdpi.com
Simple Summary Hyperthermia is a treatment for cancer patients, which consists of heating
the body to 43° C. The temperature during treatment is usually measured by placing …

Clinical applications of focused ultrasound—the brain

K Hynynen, G Clement - International Journal of Hyperthermia, 2007 - Taylor & Francis
Full article: Clinical applications of focused ultrasound—The brain Skip to Main Content Taylor
and Francis Online homepage Taylor and Francis Online homepage Access provided by The …

The principles and promising future of sonogenetics for precision medicine

P Wu, Z Liu, W Tao, Y Lai, G Yang, L Yuan - Theranostics, 2024 - pmc.ncbi.nlm.nih.gov
Sonogenetics is an emerging medical technology that uses acoustic waves to control cells
through sonosensitive mediators (SSMs) that are genetically encoded, thus remotely and …

MRIgHIFU: a tool for image‐guided therapeutics

K Hynynen - Journal of Magnetic Resonance Imaging, 2011 - Wiley Online Library
High‐intensity focused ultrasound (HIFU) provides focal delivery of mechanical energy deep
into the body. This energy can be used to elevate the tissue temperature to such a degree …

Image-guided, noninvasive, spatiotemporal control of gene expression

R Deckers, B Quesson, J Arsaut… - Proceedings of the …, 2009 - National Acad Sciences
Spatiotemporal control of transgene expression is of paramount importance in gene therapy.
Here, we demonstrate the use of magnetic resonance temperature imaging (MRI)-guided …

Short-duration-focused ultrasound stimulation of Hsp70 expression in vivo

DE Kruse, MA Mackanos… - Physics in Medicine …, 2008 - iopscience.iop.org
The development of transgenic reporter mice and advances in in vivo optical imaging have
created unique opportunities to assess and analyze biological responses to thermal therapy …

[HTML][HTML] Monitoring therapeutic response of human ovarian cancer to 17-DMAG by noninvasive PET imaging with 64Cu-DOTA-trastuzumab

G Niu, Z Li, Q Cao, X Chen - European journal of nuclear medicine and …, 2009 - Springer
Abstract Purpose 17-Dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a
heat-shock protein 90 (Hsp90) inhibitor, has been intensively investigated for cancer therapy …