The discovery of cannabinoid receptors and subsequent identification of their endogenous
ligands (endocannabinoids) in early 1990s have greatly accelerated research on …

Two types of cannabinoid receptor have been discovered so far, CB1 (2.1: CBD: 1: CB1:),
cloned in 1990, and CB2 (2.1: CBD: 2: CB2:), cloned in 1993. Distinction between these …

Objective: This review consists of three parts, representing three different possibilities of
interactions between cannabinoid receptor ligands of both exogenous and endogenous …

Freund, Tamás F., István Katona, and Daniele Piomelli. Role of Endogenous Cannabinoids
in Synaptic Signaling. Physiol Rev 83: 1017–1066, 2003; 10.1152/physrev. 00004.2003 …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

Mammalian tissues contain at least two types of cannabinoid receptor, CB1 and CB2, both
coupled to G proteins. CB1 receptors are expressed mainly by neurones of the central and …

There are at least two types of cannabinoid receptors, CB1 and CB2, both coupled to G
proteins. CB1 receptors exist primarily on central and peripheral neurons, one of their …

Cannabis (marijuana) is not only a frequently abused drug but also has the potential for the
development of useful agents for the treatment of emesis, anorexia and multiple sclerosis. In …

Cannabis has long been known to produce cognitive and emotional effects. Research has
shown that cannabinoid drugs produce these effects by driving the brain's endogenous …

The major psychoactive constituent of Cannabis sativa, Δ 9-tetrahydrocannabinol (Δ 9-THC),
and endogenous cannabinoid ligands, such as anandamide, signal through G-protein …