Multiple lines of evidence suggest a central role for the endocannabinoid system (ECS) in
the neuronal development and cognitive function and in the pathogenesis of fragile X …

Rare diseases (RDs), more than 80% of which have a genetic origin, collectively affect
approximately 350 million people worldwide. Progress in next-generation sequencing …

Autism spectrum disorder (ASD) has a multifactorial etiology. Major efforts are underway to
understand the neurobiological bases of ASD and to develop efficacious treatment …

Abstract Background Fragile X syndrome (FXS) is the most frequent cause of inherited X-
linked intellectual disability. Conventional FXS genetic testing methods mainly focus on …

The interaction between the main psychotropic ingredient of Cannabis, Δ⁹-
tetrahydrocannabinol (THC), with the endogenous cannabinoid system (ECS) is a critical …

Background The prevalence of autism spectrum disorder (ASD) increased rapidly in the last
20 years. Although related research has developed rapidly, little is known about its etiology …

The hippocampus is one of the brain areas affected by autism spectrum disorder (ASD).
Individuals with ASD typically have impairments in hippocampus-dependent learning …

Abstract Autism Spectrum Disorder (ASD) is caused by genetic, epigenetic, and
environmental factors. Mutations in the human FMR1 gene, encoding the Fragile X …

Background Fragile X syndrome (FXS) is the most common inherited cause of intellectual
disability and autism. Gene therapy may offer an efficient method to ameliorate the …

Fragile X syndrome (FXS) is an intellectual developmental disorder characterized, inter alia,
by deficits in the short-term processing of neural information, such as sensory processing …