[HTML][HTML] Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases
U Sengupta, R Kayed - Progress in neurobiology, 2022 - Elsevier
Aggregation of specific proteins are histopathological hallmarks of several
neurodegenerative diseases, such as, Amyloid β (Aβ) plaques and tau neurofibrillary …
neurodegenerative diseases, such as, Amyloid β (Aβ) plaques and tau neurofibrillary …
The human connectome in Alzheimer disease—relationship to biomarkers and genetics
The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …
resulting in cognitive impairment. The results of recent connectomics studies have now …
Microglial activation and tau propagate jointly across Braak stages
Compelling experimental evidence suggests that microglial activation is involved in the
spread of tau tangles over the neocortex in Alzheimer's disease (AD). We tested the …
spread of tau tangles over the neocortex in Alzheimer's disease (AD). We tested the …
Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective …
Background CSF and PET biomarkers of amyloid β and tau accurately detect Alzheimer's
disease pathology, but the invasiveness, high cost, and poor availability of these detection …
disease pathology, but the invasiveness, high cost, and poor availability of these detection …
[HTML][HTML] Alzheimer disease: an update on pathobiology and treatment strategies
JM Long, DM Holtzman - Cell, 2019 - cell.com
Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …
[HTML][HTML] Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer's disease
NM Lyra e Silva, RA Gonçalves, TA Pascoal… - Translational …, 2021 - nature.com
Alzheimer's disease (AD) is associated with memory impairment and altered peripheral
metabolism. Mounting evidence indicates that abnormal signaling in a brain-periphery …
metabolism. Mounting evidence indicates that abnormal signaling in a brain-periphery …
[HTML][HTML] GABAergic inhibitory interneuron deficits in Alzheimer's disease: implications for treatment
Y Xu, M Zhao, Y Han, H Zhang - Frontiers in neuroscience, 2020 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by severe
cognitive deficits and pathologically by amyloid plaques, neuronal loss, and neurofibrillary …
cognitive deficits and pathologically by amyloid plaques, neuronal loss, and neurofibrillary …
[HTML][HTML] Long-term running exercise improves cognitive function and promotes microglial glucose metabolism and morphological plasticity in the hippocampus of APP …
S Zhang, L Zhu, Y Peng, L Zhang, F Chao… - Journal of …, 2022 - Springer
Background The role of physical exercise in the prevention of Alzheimer's disease (AD) has
been widely studied. Microglia play an important role in AD. Triggering receptor expressed …
been widely studied. Microglia play an important role in AD. Triggering receptor expressed …
Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease
DP Veitch, MW Weiner, PS Aisen… - Alzheimer's & …, 2022 - Wiley Online Library
Abstract Introduction The Alzheimer's Disease Neuroimaging Initiative (ADNI) has
accumulated 15 years of clinical, neuroimaging, cognitive, biofluid biomarker and genetic …
accumulated 15 years of clinical, neuroimaging, cognitive, biofluid biomarker and genetic …
[HTML][HTML] Multi-cohort and longitudinal Bayesian clustering study of stage and subtype in Alzheimer's disease
Understanding Alzheimer's disease (AD) heterogeneity is important for understanding the
underlying pathophysiological mechanisms of AD. However, AD atrophy subtypes may …
underlying pathophysiological mechanisms of AD. However, AD atrophy subtypes may …