Glutamate transport system as a key constituent of glutamosome: molecular pathology and pharmacological modulation in chronic pain
G Gegelashvili, OJ Bjerrum - Neuropharmacology, 2019 - Elsevier
Neural uptake of glutamate is executed by the structurally related members of the SLC1A
family of solute transporters: GLAST/EAAT1, GLT-1/EAAT2, EAAC1/EAAT3, EAAT4, ASCT2 …
family of solute transporters: GLAST/EAAT1, GLT-1/EAAT2, EAAC1/EAAT3, EAAT4, ASCT2 …
High‐affinity glutamate transporters in chronic pain: An emerging therapeutic target
G Gegelashvili, OJ Bjerrum - Journal of neurochemistry, 2014 - Wiley Online Library
Neurons responsible for sensing noxious stimuli and conducting pain signals from periphery
to the spinal cord are predominantly glutamatergic. Members of the SLC1A family of high …
to the spinal cord are predominantly glutamatergic. Members of the SLC1A family of high …
Burst and tonic spinal cord stimulation differentially activate GABAergic mechanisms to attenuate pain in a rat model of cervical radiculopathy
ND Crosby, CL Weisshaar, JR Smith… - IEEE Transactions …, 2015 - ieeexplore.ieee.org
Objective: Spinal cord stimulation (SCS) is widely used to treat neuropathic pain. Burst SCS,
an alternative mode of stimulation, reduces neuropathic pain without paresthesia. However …
an alternative mode of stimulation, reduces neuropathic pain without paresthesia. However …
Use of the rat grimace scale to evaluate neuropathic pain in a model of cervical radiculopathy
BH Philips, CL Weisshaar… - Comparative …, 2017 - ingentaconnect.com
Although neck and low-back pain are common sources of neuropathic pain with high
societal costs, the pathophysiology of neuropathic pain is not well-defined. Traditionally …
societal costs, the pathophysiology of neuropathic pain is not well-defined. Traditionally …
Relevant anatomic and morphological measurements of the rat spine: considerations for rodent models of human spine trauma
NV Jaumard, J Leung, AJ Gokhale, BB Guarino… - Spine, 2015 - journals.lww.com
Study Design. Basic science study measuring anatomical features of the cervical and lumbar
spine in rat with normalized comparison with the human. Objective. The goal of this study is …
spine in rat with normalized comparison with the human. Objective. The goal of this study is …
Superoxide Dismutase‐Loaded Porous Polymersomes as Highly Efficient Antioxidants for Treating Neuropathic Pain
S Kartha, L Yan, CL Weisshaar, ME Ita… - Advanced …, 2017 - Wiley Online Library
A highly efficient antioxidant is developed by encapsulating superoxide dismutase (SOD)
within the aqueous interior of porous polymersomes. The porous polymersomes provide a …
within the aqueous interior of porous polymersomes. The porous polymersomes provide a …
Pre-treatment with meloxicam prevents the spinal inflammation and oxidative stress in DRG neurons that accompany painful cervical radiculopathy
S Kartha, CL Weisshaar, BH Philips, BA Winkelstein - Neuroscience, 2018 - Elsevier
Painful neuropathic injuries are accompanied by robust inflammatory and oxidative stress
responses that contribute to the development and maintenance of pain. After neural trauma …
responses that contribute to the development and maintenance of pain. After neural trauma …
The role of riluzole in acute traumatic cervical spinal cord injury with incomplete neurological deficit: a prospective, randomised controlled study
D Kumarasamy, VK Viswanathan, AP Shetty… - Indian Journal of …, 2022 - Springer
Introduction Riluzole, a benzothiazole sodium channel blocker is acknowledged as a
neuroprotective agent in spinal cord injury (SCI). Most of this evidence is based on pre …
neuroprotective agent in spinal cord injury (SCI). Most of this evidence is based on pre …
Inhibiting spinal secretory phospholipase A2 after painful nerve root injury attenuates established pain and spinal neuronal hyperexcitability by altering spinal …
Neuropathic injury is accompanied by chronic inflammation contributing to the onset and
maintenance of pain after an initial insult. In addition to their roles in promoting immune cell …
maintenance of pain after an initial insult. In addition to their roles in promoting immune cell …
Pain from intra-articular NGF or joint injury in the rat requires contributions from peptidergic joint afferents
JV Kras, CL Weisshaar, PS Pall, BA Winkelstein - Neuroscience letters, 2015 - Elsevier
Non-physiological stretch of the cervical facet joint's capsular ligament induces persistent
behavioral hypersensitivity and spinal neuronal hyperexcitability via an intra-articular NGF …
behavioral hypersensitivity and spinal neuronal hyperexcitability via an intra-articular NGF …