Type 2 diabetes in migrant south Asians: mechanisms, mitigation, and management

N Sattar, JMR Gill - The lancet Diabetes & endocrinology, 2015 - thelancet.com
South Asians, particularly when living in high-income countries, are at a substantially
elevated risk of type 2 diabetes compared with white Europeans, and typically develop the …

Metabolic abnormalities and obesity's impact on the risk for developing preeclampsia

FT Spradley - American Journal of Physiology-Regulatory …, 2017 - journals.physiology.org
Preeclampsia (PE), a hypertensive disorder of pregnancy, is increasing as a major
contributor to perinatal and long-term morbidity of mother and offspring. PE is thought to …

Young-onset diabetes in Asian Indians is associated with lower measured and genetically determined beta cell function

MK Siddiqui, RM Anjana, AY Dawed, C Martoeau… - Diabetologia, 2022 - Springer
Abstract Aims/hypothesis South Asians in general, and Asian Indians in particular, have
higher risk of type 2 diabetes compared with white Europeans, and a younger age of onset …

Association between hyperglycaemia and adverse perinatal outcomes in south Asian and white British women: analysis of data from the Born in Bradford cohort

D Farrar, L Fairley, G Santorelli, D Tuffnell… - The lancet Diabetes & …, 2015 - thelancet.com
Background Diagnosis of gestational diabetes predicts risk of infants who are large for
gestational age (LGA) and with high adiposity, which in turn aims to predict a future risk of …

Risk factor screening to identify women requiring oral glucose tolerance testing to diagnose gestational diabetes: a systematic review and meta-analysis and analysis …

D Farrar, M Simmonds, M Bryant, DA Lawlor, F Dunne… - PloS one, 2017 - journals.plos.org
Background Easily identifiable risk factors including: obesity and ethnicity at high risk of
diabetes are commonly used to indicate which women should be offered the oral glucose …

The identification and treatment of women with hyperglycaemia in pregnancy: an analysis of individual participant data, systematic reviews, meta-analyses and an …

D Farrar, M Simmonds, S Griffin… - Health technology …, 2016 - eprints.whiterose.ac.uk
Background Gestational diabetes mellitus (GDM) is associated with a higher risk of
important adverse outcomes. Practice varies and the best strategy for identifying and treating …

Mendelian randomization supports causality between maternal hyperglycemia and epigenetic regulation of leptin gene in newborns

C Allard, V Desgagné, J Patenaude, M Lacroix… - Epigenetics, 2015 - Taylor & Francis
Leptin is an adipokine that acts in the central nervous system and regulates energy balance.
Animal models and human observational studies have suggested that leptin surge in the …

Gestational diabetes and ultrasound-assessed fetal growth in South Asian and White European women: findings from a prospective pregnancy cohort

JS Brand, J West, D Tuffnell, PK Bird, J Wright, K Tilling… - BMC medicine, 2018 - Springer
Background Maternal gestational diabetes (GDM) is an established risk factor for large size
at birth, but its influence on intrauterine fetal growth in different ethnic populations is less …

Growing up in Bradford: protocol for the age 7–11 follow up of the Born in Bradford birth cohort

PK Bird, RRC McEachan, M Mon-Williams, N Small… - BMC public health, 2019 - Springer
Abstract Background Born in Bradford (BiB) is a prospective multi-ethnic pregnancy and
birth cohort study that was established to examine determinants of health and development …

Differences in pregnancy metabolic profiles and their determinants between White European and South Asian women: findings from the Born in Bradford cohort

K Taylor, D L. Santos Ferreira, J West, T Yang… - Metabolites, 2019 - mdpi.com
There is widespread metabolic disruption in women upon becoming pregnant. South Asians
(SA) compared to White Europeans (WE) have more fat mass and are more insulin-resistant …