Basic human functions such as breathing and digestion require mechanical stretching of
cells and tissues. However, when it comes to laboratory experiments, the mechanical …

Infection with Borrelia burgdorferi often triggers pathophysiologic perturbations that are
further augmented by the inflammatory responses of the host, resulting in the severe clinical …

Background Tick-borne diseases, caused by bacterial pathogens, pose a growing threat to
public health in Europe. This paper provides an overview of the historical context of the …

Lyme disease (LD) spirochetes are well known to be able to disseminate into the tissues of
infected hosts, including humans. The diverse strategies used by spirochetes to avoid the …

Human pathogenic bacteria circulating in the bloodstream need to find a way to interact with
endothelial cells (ECs) lining the blood vessels to infect and colonise the host. The …

Intracellular bacterial infections alter the normal functionality of human host cells and
tissues. Infection can also modify the mechanical properties of host cells, altering the …

Two years into the most significant infectious disease event of our generation, infections
have populated every conversation and in-depth understanding of host–pathogen …

Cell motility and biomechanics are critical in various (patho) physiological processes,
including the regulation of vascular barrier integrity, which can be subverted by bacterial …

Effie Bastounis recently started a lab at the University of Tübingen that studies how physical
forces guide the interactions of host cells with bacterial pathogens. Former STAR Protocols …