Cis-regulatory sequences in plants: their importance, discovery, and future challenges
The identification and characterization of cis-regulatory DNA sequences and how they
function to coordinate responses to developmental and environmental cues is of paramount …
function to coordinate responses to developmental and environmental cues is of paramount …
Absence of a simple code: how transcription factors read the genome
Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …
Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes
The precise timing of cell cycle gene expression is critical for the control of cell proliferation;
de-regulation of this timing promotes the formation of cancer and leads to defects during …
de-regulation of this timing promotes the formation of cancer and leads to defects during …
HIV latency
RF Siliciano, WC Greene - Cold Spring …, 2011 - perspectivesinmedicine.cshlp.org
HIV-1 can establish a state of latent infection at the level of individual T cells. Latently
infected cells are rare in vivo and appear to arise when activated CD4+ T cells, the major …
infected cells are rare in vivo and appear to arise when activated CD4+ T cells, the major …
CaMKII isoforms in learning and memory: localization and function
G Zalcman, N Federman, A Romano - Frontiers in molecular …, 2018 - frontiersin.org
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a key protein kinase in neural
plasticity and memory, as have been shown in several studies since the first evidence in …
plasticity and memory, as have been shown in several studies since the first evidence in …
Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity
Y Kanno, G Vahedi, K Hirahara… - Annual review of …, 2012 - annualreviews.org
T helper cell differentiation occurs in the context of the extracellular cytokine milieu evoked
by diverse microbes and other pathogenic stimuli along with T cell receptor stimulation. The …
by diverse microbes and other pathogenic stimuli along with T cell receptor stimulation. The …
Disentangling the many layers of eukaryotic transcriptional regulation
KM Lelli, M Slattery, RS Mann - Annual review of genetics, 2012 - annualreviews.org
Regulation of gene expression in eukaryotes is an extremely complex process. In this
review, we break down several critical steps, emphasizing new data and techniques that …
review, we break down several critical steps, emphasizing new data and techniques that …
The interplay between G-quadruplex and transcription
N Kim - Current medicinal chemistry, 2019 - ingentaconnect.com
G4 DNA is a non-canonical DNA structure consisting of a stacked array of Gquartets held
together by base pairing between guanine bases. The formation of G4 DNA requires a …
together by base pairing between guanine bases. The formation of G4 DNA requires a …
Quantitative MNase-seq accurately maps nucleosome occupancy levels
RV Chereji, TD Bryson, S Henikoff - Genome biology, 2019 - Springer
Micrococcal nuclease (MNase) is widely used to map nucleosomes. However, its aggressive
endo-/exo-nuclease activities make MNase-seq unreliable for determining nucleosome …
endo-/exo-nuclease activities make MNase-seq unreliable for determining nucleosome …
Functional consequences of bidirectional promoters
Several studies have shown that promoters of protein-coding genes are origins of pervasive
non-coding RNA transcription and can initiate transcription in both directions. However, only …
non-coding RNA transcription and can initiate transcription in both directions. However, only …