Epilepsy is a neurological disorder afflicting~ 65 million people worldwide. It is caused by
aberrant synchronized firing of populations of neurons primarily due to imbalance between …

Excitotoxicity is a phenomenon that describes the toxic actions of excitatory
neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of …

Astrocytes are key homeostatic regulators in the central nervous system and play important
roles in physiology. After brain damage caused by eg, status epilepticus, traumatic brain …

Epilepsy is a complex neurological syndrome characterized by seizures resulting from
neuronal hyperexcitability and sudden and synchronized bursts of electrical discharges …

Excitatory amino acid transporters (EAATs) encompass a class of five transporters with
distinct expression in neurons and glia of the central nervous system (CNS). EAATs are …

Astrocytes are specialized non-neuronal glial cells of the central nervous system,
contributing to neuronal excitability and synaptic transmission (gliotransmission). Astrocytes …

Molecular chaperones have a role to stabilize proteins or assist them in reaching their native
fold. Heat shock proteins (HSPs) are a family of molecular chaperons that protect proteins …

Abstract The Hsp70 and Hsp90 molecular chaperone systems are critical regulators of
protein homeostasis (proteostasis) in eukaryotes under normal and stressed conditions. The …

Astrocytes regulate and respond to extracellular glutamate levels in the central nervous
system (CNS) via the Na+-dependent glutamate transporters glutamate transporter-1 (GLT …

Rationale: Heat shock protein 9 (HSP90) are a family of the most highly expressed cellular
proteins and attractive drug targets against cancer, neurodegeneration diseases, etc …