Amphetamine was discovered over 100 years ago. Since then, it has transformed from a
drug that was freely available without prescription as a panacea for a broad range of …

Mesoaccumbens fibers are thought to co-release dopamine and glutamate. However, the
mechanism is unclear, and co-release by mesoaccumbens fibers has not been documented …

Vesicular monoamine transporters (VMAT) are responsible for the uptake of cytosolic
monoamines into synaptic vesicles in monoaminergic neurons. Two closely related VMATs …

Vesicular monoamine transporters (VMATs) are responsible for the packaging of
neurotransmitters such as dopamine, serotonin, norepinephrine, and epinephrine into …

Lobeline, an alkaloidal constituent of Lobelia inflata LINN., has a long history of therapeutic
usage ranging from emetic and respiratory stimulant to tobacco smoking cessation agent …

The use of new psychoactive substances (NPS) is increasing and currently> 600 NPS have
been reported. However, limited information on neuropharmacological and toxicological …

Background Treatment of stimulant-use disorders remains a formidable challenge, and the
dopamine transporter (DAT) remains a potential target for antagonist or agonist-like …

Vesicular sequestration is important in the regulation of cytoplasmic concentrations of
monoamines such as dopamine. Moreover, recent evidence suggests that increases in …

Liver-generated plasma apolipoprotein E (apoE) does not enter the brain but nonetheless
correlates with Alzheimer's disease (AD) risk and AD biomarker levels. Carriers of APOE ε4 …

In the central nervous, system, vesicular monoamine transporter 2 (VMAT2) is the only
transporter that moves cytoplasmic dopamine (DA) into synaptic vesicles for storage and …