Type I Interferons (IFNs) induce the expression of> 500 genes, which are collectively called
ISGs (IFN-stimulated genes). One of the earliest ISGs induced by IFNs is ISG15 (Interferon …

Eukaryotic proteomes are enormously sophisticated through versatile post-translational
modifications (PTMs) of proteins. A large variety of code generated via PTMs of proteins by …

HERC proteins are ubiquitin E3 ligases of the HECT family. The HERC subfamily is
composed of six members classified by size into large (HERC1 and HERC2) and small …

Abnormal nuclear structure caused by dysregulation of skeletal proteins is a common
phenomenon in tumour cells. However, how skeletal proteins promote tumorigenesis …

Identification of genes dysregulated during the hepatitis B virus (HBV)-host cell interaction
adds to the understanding of underlying molecular mechanisms and aids in discovering …

Background Oxidative stress (OS) is key to various diseases and is implicated in cancer
progression and oncogenesis. However, the potential diagnostic value of OS-related genes …

The tripartite motif (TRIM) family proteins are a group of proteins involved in different
signaling pathways. The changes in the expression regulation, function, and signaling of this …

Acute myeloid leukemia (AML), the most common form of an acute leukemia, is a malignant
disorder of stem cell precursors of the myeloid lineage. Ubiquitination is one of the post …

The mechanism by which ubiquitin‑specific protease 18 (USP18)(enzyme commission: 3.4.
19.12) inhibition in cancer promotes cell pyroptosis via the induction of interferon (IFN) …

目的探讨干扰素刺激基因15 (ISG15) 蛋白在原发性肝细胞癌(HCC) 中的表达水平及其临床预后
价值. 方法选取2018 年1 月至2020 年10 月该院经术后病理确诊的HCC 患者100 例 …