[HTML][HTML] Flavonoids against the SARS-CoV-2 induced inflammatory storm
The disease severity of COVID-19, especially in the elderly and patients with co-morbidities,
is characterized by hypercytokinemia, an exaggerated immune response associated with an …
is characterized by hypercytokinemia, an exaggerated immune response associated with an …
Heme oxygenase-1 modulation: A potential therapeutic target for COVID-19 and associated complications
D Singh, H Wasan, KH Reeta - Free Radical Biology and Medicine, 2020 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) continues to infect hundred thousands of people …
syndrome coronavirus 2 (SARS-CoV-2) continues to infect hundred thousands of people …
5-Methoxyflavone-induced AMPKα activation inhibits NF-κB and P38 MAPK signaling to attenuate influenza A virus-mediated inflammation and lung injury in vitro and …
S Yang, L Wang, X Pan, Y Liang, Y Zhang, J Li… - Cellular & Molecular …, 2022 - Springer
Influenza-related acute lung injury (ALI) is a life-threatening condition that results mostly
from uncontrolled replication of influenza virus (IV) and severe proinflammatory responses …
from uncontrolled replication of influenza virus (IV) and severe proinflammatory responses …
Regulation of host immune responses against influenza A virus infection by mitogen-activated protein kinases (MAPKs)
J Yu, X Sun, JYG Goie, Y Zhang - Microorganisms, 2020 - mdpi.com
Influenza is a major respiratory viral disease caused by infections from the influenza A virus
(IAV) that persists across various seasonal outbreaks globally each year. Host immune …
(IAV) that persists across various seasonal outbreaks globally each year. Host immune …
A journey into the clinical relevance of heme oxygenase 1 for human inflammatory disease and viral clearance: why does it matter on the COVID-19 scene?
Heme oxygenase 1 (HO-1), the rate-limiting enzyme in heme degradation, is involved in the
maintenance of cellular homeostasis, exerting a cytoprotective role by its antioxidative and …
maintenance of cellular homeostasis, exerting a cytoprotective role by its antioxidative and …
The different facets of heme-oxygenase 1 in innate and adaptive immunity
RCMC Silva, LR Vasconcelos… - Cell Biochemistry and …, 2022 - Springer
Heme oxygenase (HO) enzymes are responsible for the main oxidative step in heme
degradation, generating equimolar amounts of free iron, biliverdin and carbon monoxide …
degradation, generating equimolar amounts of free iron, biliverdin and carbon monoxide …
Hyperoside inhibits EHV-8 infection via alleviating oxidative stress and IFN production through activating JNK/Keap1/Nrf2/HO-1 signaling pathways
T Wang, L Hu, R Li, H Ren, S Li, Q Sun, X Ding… - Journal of …, 2024 - Am Soc Microbiol
ABSTRACT Equine herpesvirus type 8 (EHV-8) causes abortion and respiratory disease in
horses and donkeys, leading to serious economic losses in the global equine industry …
horses and donkeys, leading to serious economic losses in the global equine industry …
Induction of HOXA3 by porcine reproductive and respiratory syndrome virus inhibits type I interferon response through negative regulation of HO-1 transcription
Y Feng, X Guo, H Tian, Y He, Y Li, X Jiang… - Journal of …, 2022 - Am Soc Microbiol
ABSTRACT Type I interferons (IFN-Is) play a key role in host defense against virus infection,
but porcine reproductive and respiratory syndrome virus (PRRSV) infection does not …
but porcine reproductive and respiratory syndrome virus (PRRSV) infection does not …
Interpretation of the anti-influenza active ingredients and potential mechanisms of Ge Gen Decoction based on spectrum-effect relationships and network analysis
X Liu, S Ke, X Wang, Y Li, J Lyu, Y Liu… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Ge Gen Decoction (GGD) is a classic traditional
Chinese medicine (TCM) prescription that originated in the ancient Chinese medical book …
Chinese medicine (TCM) prescription that originated in the ancient Chinese medical book …
Effects and mechanism of Aβ1−42 on EV-A71 replication
M Zhong, H Wang, H Yan, S Wu, K Wang, L Yang… - Virology Journal, 2022 - Springer
Background β-Amyloid (Aβ) protein is a pivotal pathogenetic factor in Alzheimer's disease
(AD). However, increasing evidence suggests that the brain has to continuously produce …
(AD). However, increasing evidence suggests that the brain has to continuously produce …