Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …

Nerve growth factor (NGF) is essential for the survival of sensory and sympathetic neurons
during development. However, in the adult, NGF and its interaction with tropomyosin …

These updated guidelines present a practical and logical approach to the assessment and
management of acute and chronic pain in canine and feline patients. Recognizing pain is …

Animal sentience refers to the capacity of animals to feel both positive and negative
emotions including that of pain. As veterinary health professionals, we have a medical and …

The '2021 AAFP Feline Senior Care Guidelines' are authored by a Task Force of experts in
feline clinical medicine and serve as an update and extension of those published in 2009 …

Background Frunevetmab, a felinized antinerve growth factor monoclonal antibody,
effectively decreases osteoarthritis (OA) pain in cats. Objective To evaluate the efficacy of …

Failure of analgesic drugs in clinical development is common. Along with the current
“reproducibility crisis” in pain research, this has led some to question the use of animal …

Background Osteoarthritis (OA) is a common progressive joint disease in dogs and cats. The
goal of OA treatment is to reduce inflammation, minimize pain, and maintain joint function …

A literature review identified six placebo‐controlled studies of analgesics in client‐owned
cats with degenerative joint disease‐associated pain. Five studies with 96 cats had …

Background Gabapentin is the most commonly prescribed medication for the treatment of
chronic musculoskeletal pain in cats. Despite this common and chronic usage, clinically …