Background. Young people in sub-Saharan Africa (SSA) are disproportionately affected by
HIV, sexually transmitted infections and unplanned pregnancies. The provision of accessible …

Background: Adolescents are a unique population with significant unmet health needs. They
are often excluded from research that may benefit them as they are perceived as vulnerable …

Adolescents face a higher risk for HIV, STIs, and unintended pregnancy than any other age
group in sub–Saharan Africa, and have unique health care needs as they navigate this …

Purpose One third of people newly living with HIV/AIDS are adolescents. Research on
adolescent HIV prevention is critical owing to differences between adolescents and adults …

Ethics guidelines emphasise that research should be acceptable to the people invited to
take part. However, acceptability is subjective and dependent on context, complicating its …

Abstract Background The South African legal framework requires mandatory parental/legal
guardian consent for all research with children. Ethics guidelines provide some reprieve by …

The design of HIV prevention trials in the context of effective HIV preventive methods is a
challenge. Alternate designs, including using non-randomised 'observational control arms' …

Background Fisherfolks (FF) and female sex workers (FSW) in Uganda could be suitable key
populations for HIV vaccine efficacy trials because of the high HIV incidence and good …

An Adolescent Seeking HIV Prophylaxis A 16-year-old boy was seen in the infectious
disease clinic for consideration of preexposure prophylaxis against human …

Introduction Vaccine efficacy testing requires engagement of willing volunteers with high
disease incidence. We evaluated factors associated with willingness to participate in …