Tubulin dynamics is a promising target for new chemotherapeutic agents. The colchicine
binding site is one of the most important pockets for potential tubulin polymerization …

A growing solid tumor relies on a developing vasculature to meet its needs in terms of
oxygen, nutrients, depuration, etc. This implies that if the vascular bed that has developed …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

It is over 50 years since the discovery of microtubules, and they have become one of the
most important drug targets for anti-cancer therapies. Microtubules are predominantly …

Tubulin protein is one of several members of a small family of globular proteins. It offers a
potential target for anticancer drug design and development. Combretastatin A-4 (CA-4) is a …

Colchicine site ligands with indole B rings are potent tubulin polymerization inhibitors.
Structural modifications at the indole 3-position of 1-methyl-5-indolyl-based …

Isocombretastatins A are 1, 1-diarylethene isomers of combretastatins A. We have
synthesized the isomers of combretastatin A-4, deoxycombretastatin A-4, 3-amino …

The natural product combretastatin A-4 (CA4) is a potent anti-cancer agent known for its
antimitotic and antiangiogenic properties. The basic structure of CA4 has inspired the design …

Tubulin Polymerization Inhibitors (TPIs) are promising ligands utilized in chemotherapy for
modern cancer treatment. However, the current TPIs exhibit many serious side effects that …

The McMurry coupling reaction has been recognized as one of the most efficient methods for
the synthesis of alkenes from carbonyl compounds. This reaction can be applied to the …