In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair …

Iron as an important element plays crucial roles in various physiological and pathological
processes. Iron metabolism behaves in systemic and cellular two levels that usually are in …

Although the serum-abundant metal-binding protein transferrin (encoded by the Trf gene) is
synthesized primarily in the liver, its function in the liver is largely unknown. Here, we …

Single-cell transcriptomics provide a systematic map of gene expression in different human
cell types. The next challenge is to systematically understand cell-type-specific gene …

A greater understanding of hematopoietic stem cell (HSC) regulation is required for
dissecting protective versus detrimental immunity to pathogens that cause chronic infections …

In this study, we detail a novel approach that combines bacterial fitness fluorescent reporter
strains with scRNA-seq to simultaneously acquire the host transcriptome, surface marker …

It is critical to understand how human quiescent long-term hematopoietic stem cells (LT-
HSCs) sense demand from daily and stress-mediated cues and then transition into …

Host microbiota crosstalk is essential for the production and functional modulation of blood-
cell lineages. Whether, and if so how, the microbiota influences hematopoietic stem cells …

Leukemia inhibitory factor (LIF), an indispensable bioactive protein that sustains self‐
renewal and pluripotency in stem cells, is vital for mouse embryonic stem cell (mESC) …

Ferroptosis, a new type of non-apoptotic cell death modality, is different from other modes of
cell death and has been primarily found in tumor cells. Previous studies have reported that …