Insulin has important vascular actions to stimulate production of nitric oxide from
endothelium. This leads to capillary recruitment, vasodilation, increased blood flow, and …

Although diabetes is recognized as a potent and prevalent risk factor for ischemic heart
disease, less is known as to whether diabetes causes an altered cardiac phenotype …

Long-chain acyl-coenzyme A (LC-CoA) is a crucial metabolic intermediate that plays
important cellular regulatory roles, including activation and inhibition of ion channels. The …

ATP sensitive potassium channels (KATP) are so named because they open as cellular ATP
levels fall. This leads to membrane hyperpolarization and thus links cellular metabolism to …

ATP-sensitive potassium (KATP) channels are present in the surface and internal
membranes of cardiac, skeletal, and smooth muscle cells and provide a unique feedback …

Long-chain fatty acyl-CoA esters are key intermediates in numerous lipid metabolic
pathways, and recognized as important cellular signaling molecules. The intracellular flux …

Despite our cognizance that diabetes can enhance the chances of heart failure, causes
multiorgan failure, and contributes to morbidity and mortality, it is rapidly increasing menace …

Epidemiologic as well as clinical studies confirm the close link between diabetes mellitus
and heart failure. Diabetic cardiomyopathy (DCM) is still a poorly understood" entity" …

Diazoxide and 5‐hydroxydecanoate (5‐HD; C10: 0) are reputed to target specifically
mitochondrial ATP‐sensitive K+ (KATP) channels. Here we describe KATP channel …

Diabetic cardiomyopathy has been defined as “a distinct entity characterized by the
presence of abnormal myocardial performance or structure in the absence of epicardial …