Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …

N ε-lysine acetylation was discovered more than half a century ago as a post-translational
modification of histones and has been extensively studied in the context of transcription …

SMC (structural maintenance of chromosomes) protein complexes are an evolutionarily
conserved family of motor proteins that hold sister chromatids together and fold genomes …

SMC (structural maintenance of chromosomes) complexes—which include condensin,
cohesin and the SMC5–SMC6 complex—are major components of chromosomes in all …

As a ring-shaped adenosine triphosphatase (ATPase) machine, cohesin organizes the
eukaryotic genome by extruding DNA loops and mediates sister chromatid cohesion by …

The accurate and complete replication of genomic DNA is essential for all life. In eukaryotic
cells, the assembly of the multi-enzyme replisomes that perform replication is divided into …

Lysine acetylation is a reversible posttranslational modification of proteins and plays a key
role in regulating gene expression. Technological limitations have so far prevented a global …

The cohesin complex is a major constituent of interphase and mitotic chromosomes. Apart
from its role in mediating sister chromatid cohesion, it is also important for DNA double …

Abstract Cornelia de Lange syndrome (CdLS) is a dominantly inherited congenital
malformation disorder, caused by mutations in the cohesin-loading protein NIPBL, for nearly …

Cells primarily rely on proteins to perform the majority of their physiological functions, and
the function of proteins is regulated by post‑translational modifications (PTMs). The …