Kynurenine pathway (KP) is the primary path of tryptophan (Trp) catabolism in most
mammalian cells. The KP generates several bioactive catabolites, such as kynurenine (Kyn) …

Abdominal Aortic Aneurysm (AAA) affects 4–5% of men over 65, and Aortic Dissection (AD)
is a life-threatening aortic pathology associated with high morbidity and mortality. Initiators of …

Aneurysm of the abdominal aorta (AAA) is a particular, specifically localized form of
atherothrombosis, providing a unique human model of this disease. The pathogenesis of …

Current management of aortic aneurysms relies exclusively on prophylactic operative repair
of larger aneurysms. Great potential exists for successful medical therapy that halts or …

Background—Doxycycline has been shown to effectively inhibit aneurysm formation in
animal models of abdominal aortic aneurysm. Although this effect is ascribed to matrix …

The matrix metalloproteinases (MMPs) are 23 secreted or cell surface proteases that act
together and with other protease classes to turn over the extracellular matrix, cleave cell …

Cystatin C (cys-C) is a small protein molecule (120 amino acid peptide chain, approximately
13kDa) produced by virtually all nucleated cells in the human body. It belongs to the family …

We provide the first comprehensive analysis of the extracellular matrix (ECM) composition of
peri-islet capsules, composed of the peri-islet basement membrane (BM) and subjacent …

Abdominal aortic aneurysm (AAA) is a severe vascular disease and a major public health
issue with an unmet medical need for therapy. This disease is featured by a progressive …

Abdominal aortic aneurysm (AAA) is an important health problem. Elective surgical
treatment is recommended on the basis of an individual's risk of rupture, which is predicted …