Harnessing genomic information for livestock improvement
M Georges, C Charlier, B Hayes - Nature Reviews Genetics, 2019 - nature.com
The world demand for animal-based food products is anticipated to increase by 70% by
2050. Meeting this demand in a way that has a minimal impact on the environment will …
2050. Meeting this demand in a way that has a minimal impact on the environment will …
Interferon regulatory factor 7 in inflammation, cancer and infection
F Qing, Z Liu - Frontiers in Immunology, 2023 - frontiersin.org
Interferon regulatory factor 7 (IRF7), a member of the interferon regulatory factors (IRFs)
family, is located downstream of the pattern recognition receptors (PRRs)-mediated …
family, is located downstream of the pattern recognition receptors (PRRs)-mediated …
[HTML][HTML] A major role for ferroptosis in Mycobacterium tuberculosis–induced cell death and tissue necrosis
Necrotic cell death during Mycobacterium tuberculosis (Mtb) infection is considered host
detrimental since it facilitates mycobacterial spread. Ferroptosis is a type of regulated …
detrimental since it facilitates mycobacterial spread. Ferroptosis is a type of regulated …
The tuberculous granuloma and preexisting immunity
Pulmonary granulomas are widely considered the epicenters of the immune response to
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). Recent animal …
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). Recent animal …
Mycobacterium tuberculosis: success through dormancy
M Gengenbacher, SHE Kaufmann - FEMS microbiology reviews, 2012 - academic.oup.com
Tuberculosis (TB) remains a major health threat, killing nearly 2 million individuals around
this globe, annually. The only vaccine, developed almost a century ago, provides limited …
this globe, annually. The only vaccine, developed almost a century ago, provides limited …
In search of a new paradigm for protective immunity to TB
C Nunes-Alves, MG Booty, SM Carpenter… - Nature Reviews …, 2014 - nature.com
Clinical trials of vaccines against Mycobacterium tuberculosis are well under way and
results are starting to come in. Some of these results are not so encouraging, as exemplified …
results are starting to come in. Some of these results are not so encouraging, as exemplified …
Cell-mediated immune responses in tuberculosis
AM Cooper - Annual review of immunology, 2009 - annualreviews.org
Tuberculosis is primarily a disease of the lung, and dissemination of the disease depends
on productive infection of this critical organ. Upon aerosol infection with Mycobacterium …
on productive infection of this critical organ. Upon aerosol infection with Mycobacterium …
Cavitary tuberculosis: the gateway of disease transmission
ME Urbanowski, AA Ordonez… - The Lancet Infectious …, 2020 - thelancet.com
Tuberculosis continues to be a major threat to global health. Cavitation is a dangerous
consequence of pulmonary tuberculosis associated with poor outcomes, treatment relapse …
consequence of pulmonary tuberculosis associated with poor outcomes, treatment relapse …
Are innate immune signaling pathways in plants and animals conserved?
FM Ausubel - Nature immunology, 2005 - nature.com
Although adaptive immunity is unique to vertebrates, the innate immune response seems to
have ancient origins. Common features of innate immunity in vertebrates, invertebrate …
have ancient origins. Common features of innate immunity in vertebrates, invertebrate …
[HTML][HTML] A half-century of research on tuberculosis: Successes and challenges
BR Bloom - The Journal of Experimental Medicine, 2023 - ncbi.nlm.nih.gov
Great progress has been made over the past half-century, but TB remains a formidable
global health problem, particularly in low-and middle-income countries. Understanding the …
global health problem, particularly in low-and middle-income countries. Understanding the …