Cisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is
limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can …

Simple Summary Nephrotoxicity is the dose-limiting factor of cisplatin treatment.
Nephrotoxicity is characterized by reduced kidney function. Although an often-reversible …

Acute kidney injury (AKI) is characterized by mitochondrial dysfunction and activation of the
innate immune system. The cyclic GMP-AMP synthase (cGAS) stimulator of interferon genes …

Cisplatin is one of the most widely used chemotherapeutic agents for various solid tumors in
the clinic due to its high efficacy and broad spectrum. The antineoplastic activity of cisplatin …

Acute kidney injury (AKI) is a heterogeneous clinical syndrome that has multiple aetiologies,
variable pathogenesis and diverse outcomes. However, these heterogeneities are not …

Background Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective
chemotherapeutic agents. However, its clinical use is limited due to the severe side effects …

Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents
to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors. A …

Cisplatin is one of the most widely-used drugs to treat cancers. However, its nephrotoxic and
ototoxic side-effects remain major clinical limitations. Recent studies have improved our …

Blood urea nitrogen and serum creatinine are imperfect markers of kidney function because
they are influenced by many renal and nonrenal factors independent of kidney function. A …

Acute kidney injury (AKI) prolongs hospital stay and increases mortality in various clinical
settings. Ischaemia–reperfusion injury (IRI), nephrotoxic agents and infection leading to …